Results 41 to 50 of about 12,403 (212)

Multifaceted roles of HSF1 in cancer

Tumor Biology, 2015
Heat shock transcription factor 1 (HSF1) is the master regulator of the heat shock response. Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and could serve as an independent diagnostic or prognostic biomarker. In this review, we will provide an overview of the multifaceted
Sufang, Jiang, Kailing, Tu, Qiang, Fu, David C, Schmitt, Lan, Zhou, Na, Lu, Yuhua, Zhao   +6 more
openaire   +2 more sources

PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

Cells, 2022
At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu, Yingtong Lin, Xiaoyun Zeng, Chan Yang, Siqin Duan, Liqiong Ding, Wanzhen Lu, Jian Lin, Xiaoyan Pan, Xiancai Ma, Shuwen Liu   +10 more
doaj   +1 more source

Pleiotropic Role of HSF1 in Neoplastic Transformation [PDF]

Current Cancer Drug Targets, 2014
HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a ...
Vydra, Natalia, Toma, Agnieszka, Widlak, Wieslawa   +2 more
openaire   +2 more sources

Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity

Cell Reports, 2018
Summary: Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of a ...
Xu Zheng, Ali Beyzavi, Joanna Krakowiak, Nikit Patel, Ahmad S. Khalil, David Pincus   +5 more
doaj   +1 more source

Hsf1 Knock-out

Journal of Biological Chemistry, 2011
In the recent article by Tranter et al. (1), it is indicated that homozygous Hsf1 (knock-out) mice are not viable. This information as mentioned was not supported by any reference. As statements provided in scientific papers need to be accurate, I would like to provide the following additional information and correction.
openaire   +2 more sources

Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively. [PDF]

PLoS ONE, 2014
Stationary-phase cultures have been used as an important model of aging, a complex process involving multiple pathways and signaling networks. However, the molecular processes underlying stress response of non-dividing cells are poorly understood ...
Inbal Nussbaum, Esther Weindling, Ritta Jubran, Aviv Cohen, Shoshana Bar-Nun   +4 more
doaj   +1 more source

The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model. [PDF]

PLoS ONE, 2016
Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of ...
Chase D Powell, Trillitye R Paullin, Candice Aoisa, Christopher J Menzie, Ashley Ubaldini, Sandy D Westerheide   +5 more
doaj   +1 more source

HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression

Reproductive Biology and Endocrinology, 2021
Background Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which brings physical and mental pain to patients and their families ...
Yixin Wang, Jing Xiu, Tingting Yang, Chune Ren, Zhenhai Yu   +4 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source