Results 81 to 90 of about 12,403 (212)

The potential of ethanolic extract of Moringa oleifera leaves on HSF1 expression in oral cancer induced by benzo[a]pyrene

Dental Journal, 2020
Background: Oral cancer is the sixth most common malignancy that occurs in the world, with more than 330,000 deaths a year. In cancer, mutations occur in proteins, accompanied by unfolding proteins, caused by the unstable micro-environment in cells.
Vania Syahputri, Theresia Indah Budhy, Bambang Sumaryono   +2 more
doaj   +1 more source

HSF1 is a novel prognostic biomarker in high-risk prostate cancer that correlates with ferroptosis [PDF]

, 2023
Gaozhen Jia, Wenbo Wu, Lei Chen, Yang Yu, QiLin Tang, Haitao Liu, Qi Jiang, Bangmin Han   +7 more
openalex   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Reply to Christians: Hsf1 Knock-out

Journal of Biological Chemistry, 2011
This is a response to a letter by Christians (1) In response to the letter by Christians asserting viability of HSF-1 knock-out (KO) mice, we acknowledge that our statement that “the homozygous mice are lethal” was an oversimplification, and we apologize for this. To set the record straight, HSF-1 KO mice have been created, and a small percentage of
W. Keith Jones, Michael Tranter
openaire   +1 more source

Author Response: Hsf1 and the molecular chaperone Hsp90 support a “rewiring stress response” leading to an adaptive cell size increase in chronic stress

, 2023
Samarpan Maiti, Kaushik Bhattacharya, Diana Wider, Dina Hany, Olesya O. Panasenko, Lilia Bernasconi, Nicolas Hulo, Didier Picard   +7 more
openalex   +2 more sources

Heat Therapy: Targeting Health, Disease, and Disability

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
The predominance of evidence suggests heat therapy has an impact on all aspects of health and performance, but the drivers of that improvement, the extent to which they are improved, and the specific populations in which improvements manifest are far from completely understood.
Rauchelle E. Richey, Robert D. Hyldahl, Brendan W. Kaiser, Paige C. Geiger, John R. Halliwill, Christopher T. Minson   +5 more
wiley   +1 more source

Hypercapnia Effects on Lung Function

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
CO2 is a signaling molecule that disrupts alveolar fluid clearance and ion transport, impairs alveolar repair, and promotes mitochondrial and endoplasmic reticulum dysfunction. It suppresses innate immunity, host defense, and inflammation, while increasing airway contractility.
Seungseo Choi, Laura A. Dada, Jacob I. Sznajder   +2 more
wiley   +1 more source

HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response [PDF]

, 2020
Arpit Katiyar, Mitsuaki Fujimoto, Ke Tan, Ai Kurashima, Pratibha Srivastava, Mariko Okada, Ryosuke Takii, Akira Nakai   +7 more
openalex   +1 more source

Reduced Proteasome Degradation of HSF‐1 Shifts Protein Stress Management With Age in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 2, February 2026.
Ageing C. elegans prioritises chronic protein stress protection over acute stress response by coordinating HSF‐1 activity. Decreased PBS‐7 binding in aged worms reduces HSF‐1 degradation, enhancing its ability to upregulate protective factors against accumulating protein aggregates while simultaneously suppressing its activation under acute heat shock.
Hongwei Wang, Fengzhen Sun, Zhidong He, Xiaojie Wang, Hao Liu, Mengjiao Song, Qingxia Chen, Zhixue Li, Ligang Wu, Xiumin Yan, Xueliang Zhu, Yidong Shen   +11 more
wiley   +1 more source

Direct activation of HSF1 by macromolecular crowding and misfolded proteins.

PLoS ONE
Stress responses play a vital role in cellular survival against environmental challenges, often exploited by cancer cells to proliferate, counteract genomic instability, and resist therapeutic stress.
Oliver Simoncik, Vlastimil Tichy, Michal Durech, Lenka Hernychova, Filip Trcka, Lukas Uhrik, Miroslav Bardelcik, Philip J Coates, Borivoj Vojtesek, Petr Muller   +9 more
doaj   +1 more source