Results 11 to 20 of about 39,355 (215)
Український журнал Здоров'я жінки, 2023 Епізіотомія, подібно до інших хірургічних втручань, активує запальні процеси в організмі, залучаючи прозапальні маркери, такі як інтерлейкіни, цитокіни і простагландини.
M.B. Liashko, D.O. Govsieiev
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Heat Shock Protein 60 in Cardiovascular Physiology and Diseases
Frontiers in Molecular Biosciences, 2020 Heat shock protein 60 (HSP60) is a highly conserved protein abundantly expressed in both prokaryotic and eukaryotic cells. In mammals, HSP60 has been primarily considered to reside in the mitochondria, where HSP60 and HSP10 form a complex and facilitate ...
Yaoyun Duan +5 more
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Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis [PDF]
, 1989 Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides.
Hartl, Franz-Ulrich +3 more
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Djhsp60 Is Required for Planarian Regeneration and Homeostasis
Biomolecules, 2022 HSP60, a well-known mitochondrial chaperone, is essential for mitochondrial homeostasis. HSP60 deficiency causes dysfunction of the mitochondria and is lethal to animal survival.
Kexue Ma +7 more
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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]
, 2011 Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham +49 more
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Hsp60 Regulation of Tumor Cell Apoptosis [PDF]
Journal of Biological Chemistry, 2008 Molecular chaperones may promote cell survival, but how this process is regulated, especially in cancer, is not well understood. Using high throughput proteomics screening, we identified the cell cycle regulator and apoptosis inhibitor survivin as a novel protein associated with the molecular chaperone Hsp60.
Ghosh, Jagadish C. +3 more
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Journal of Diabetes Research, 2014 Adipocytes release immune mediators that contribute to diabetes-associated inflammatory processes. As the stress protein heat shock protein 60 (Hsp60) induces proinflammatory adipocyte activities, we hypothesized that adipocytes of diabetes-predisposed ...
Tina Märker +4 more
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Sorting pathways of mitochondrial inner membrane proteins [PDF]
, 1990 Two distinct pathways of sorting and assembly of nuclear-encoded mitochondrial inner membrane proteins are described. In the first pathway, precursor proteins that carry amino-terminal targeting signals are initially translocated via contact sites ...
Hartl, Franz-Ulrich +5 more
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HSP60, Bax, Apoptosis and the Heart [PDF]
Journal of Cellular and Molecular Medicine, 2005 HSP60 has primarily been known as a mitochondrial protein that is important for folding key proteins after import into the mitochondria. It is now clear that a significant amount of HSP60 is also present in the extra-mitochondrial cytosol of many cells. In the heart, this cytosolic HSP60 complexes with Bax, Bak and Bcl-XL, but not with Bcl-2. Reduction
S, Gupta, A A, Knowlton
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Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]
, 2019 The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F. +4 more
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