Results 11 to 20 of about 40,103 (213)
Heat shock protein 10 as a chaperone modulating α-synuclein amyloid fibril formation. [PDF]
Protein SciAbstract HSP10 is a well‐known human co‐chaperone that interacts with HSP60 to comprise the HSP60/10 chaperonin complex which upholds mitochondrial proteostasis. HSP10 also demonstrates independent roles in binding to misfolded proteins and interacts with several amyloidogenic client proteins.
Larsson JNK +5 more
europepmc +2 more sources
Heat Shock Protein 60 in Cardiovascular Physiology and Diseases
Frontiers in Molecular Biosciences, 2020 Heat shock protein 60 (HSP60) is a highly conserved protein abundantly expressed in both prokaryotic and eukaryotic cells. In mammals, HSP60 has been primarily considered to reside in the mitochondria, where HSP60 and HSP10 form a complex and facilitate ...
Yaoyun Duan +5 more
doaj +1 more source
Curcumin affects HSP60 folding activity and levels in neuroblastoma cells [PDF]
, 2020 The fundamental challenge in fighting cancer is the development of protective agents able to interfere with the classical pathways of malignant transformation, such as extracellular matrix remodeling, epithelial\u2013mesenchymal transition and ...
Campanella C. +9 more
core +2 more sources
Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis [PDF]
, 1989 Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides.
Hartl, Franz-Ulrich +3 more
core +1 more source
Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis. [PDF]
PLoS ONE, 2013 Myalgic encephalomyelitis (ME, also called Chronic Fatigue Syndrome), a common disease with chronic fatigability, cognitive dysfunction and myalgia of unknown etiology, often starts with an infection.
Amal Elfaitouri +8 more
doaj +1 more source
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]
, 2011 Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham +49 more
core +3 more sources
Український журнал Здоров'я жінки, 2023 Епізіотомія, подібно до інших хірургічних втручань, активує запальні процеси в організмі, залучаючи прозапальні маркери, такі як інтерлейкіни, цитокіни і простагландини.
M.B. Liashko, D.O. Govsieiev
doaj +1 more source
Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]
, 2019 The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F. +4 more
core +1 more source
Hsp60 Regulation of Tumor Cell Apoptosis [PDF]
Journal of Biological Chemistry, 2008 Molecular chaperones may promote cell survival, but how this process is regulated, especially in cancer, is not well understood. Using high throughput proteomics screening, we identified the cell cycle regulator and apoptosis inhibitor survivin as a novel protein associated with the molecular chaperone Hsp60.
Ghosh, Jagadish C. +3 more
openaire +3 more sources
Journal of Diabetes Research, 2014 Adipocytes release immune mediators that contribute to diabetes-associated inflammatory processes. As the stress protein heat shock protein 60 (Hsp60) induces proinflammatory adipocyte activities, we hypothesized that adipocytes of diabetes-predisposed ...
Tina Märker +4 more
doaj +1 more source