Results 31 to 40 of about 40,103 (213)

Disease-associated mutations in the HSPD1 gene encoding the large subunit of the mitochondrial HSP60/HSP10 chaperonin complex

Frontiers in Molecular Biosciences, 2016
Heat shock protein 60 (HSP60) forms together with heat shock protein 10 (HSP10) double-barrel chaperonin complexes that are essential for folding to the native state of proteins in the mitochondrial matrix space.
Peter Bross, Paula Fernandez-Guerra
doaj   +1 more source

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

The Journal of Clinical Investigation, 2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra   +14 more
doaj   +1 more source

HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells

Redox Biology, 2019
HSP60 is a major mitochondrial chaperone for maintaining mitochondrial proteostasis. Our previous studies showed that HSP60 was significantly downregulated in clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer characterized by
Ruifang Teng, Zongyuan Liu, Haiping Tang, Wenhao Zhang, Yuling Chen, Renhua Xu, Liang Chen, Jiangping Song, Xiaohui Liu, Haiteng Deng   +9 more
doaj   +1 more source

Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer. [PDF]

PLoS ONE, 2014
Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with
Xiao-shan Li, Qing Xu, Xiang-yang Fu, Wei-sheng Luo   +3 more
doaj   +1 more source

Mitochondrial molecular chaperones [PDF]

, 1994
After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio, Caplan, Caplan, Cheng, Craig, Cyr, Deshales, Eilers, Gambill, Glick, Glick, Hartl, Hartl, Hwang, Johnson, Kang, Kiebler, Langer, Liberek, Manning-Krieg, Neupert, Ostermann, Palleros, Rassow, Rospert, Sanders, Scherer, Schleyer, Schröder, Simon, Vestweber, Voos, Xia   +32 more
core   +1 more source

HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis

Molecular Metabolism
Objective: Mitochondrial proteostasis is critical for cellular function. The molecular chaperone HSP60 is essential for cell function and dysregulation of HSP60 expression has been implicated in cancer and diabetes.
Cagla Cömert, Kasper Kjær-Sørensen, Jakob Hansen, Jasper Carlsen, Jesper Just, Brandon F. Meaney, Elsebet Østergaard, Yonglun Luo, Claus Oxvig, Lisbeth Schmidt-Laursen, Johan Palmfeldt, Paula Fernandez-Guerra, Peter Bross   +12 more
doaj   +1 more source

Cord blood CD4+ T cells respond to self heat shock protein 60 (HSP60). [PDF]

PLoS ONE, 2011
BACKGROUND: To prevent harmful autoimmunity most immune responses to self proteins are controlled by central and peripheral tolerance. T cells specific for a limited set of self-proteins such as human heat shock protein 60 (HSP60) may contribute to ...
Joost A Aalberse, Berber Kapitein, Sytze de Roock, Mark R Klein, Wilco de Jager, Ruurd van der Zee, Maarten O Hoekstra, Femke van Wijk, Berent J Prakken   +8 more
doaj   +1 more source

Chaperonopathies and Chaperonotherapy. Hsp60 as Therapeutic Target in Cancer: Potential Benefits and Risks. [PDF]

, 2013
In this minireview we focus on Hsp60 as a target for anticancer therapy. We discuss the new concepts of chaperonopathies and chaperonotherapy and present information on Hsp60 localization in the cell membrane of human tumor cells.
Angileri, Francesca, Cappello, F, Conway de Macario, E, Macario, AJL   +3 more
core   +1 more source

HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide

Poultry Science
HSP60 is implicated in many biological functions and plays a key role in maintaining oxidative stress and preserving mitochondrial integrity. Our previous study showed that HSP60 inhibits apoptosis. In this study, we further investigated the mechanism of
Shengliang Cao, Yanlan Li, Lele Chen, Xiaojing Lei, Xiujuan Feng, Yubao Li   +5 more
doaj   +1 more source

Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs. [PDF]

, 2014
BackgroundSustained inflations (SI) are used with the initiation of ventilation at birth to rapidly recruit functional residual capacity and may decrease lung injury and the need for mechanical ventilation in preterm infants.
Hillman, Noah H, Jobe, Alan H, Kallapur, Suhas G, Kemp, Matthew W, Miura, Yuichiro   +4 more
core   +6 more sources