Results 41 to 50 of about 170,313 (323)
Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. [PDF]
, 2017 BACKGROUND: Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation.
Brock, Hugh W +4 more
core +2 more sources
Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70) [PDF]
Current Topics in Medicinal Chemistry, 2016 Heat shock protein 70 (Hsp70) is a molecular chaperone that plays critical roles in protein homeostasis. Hsp70's chaperone activity is coordinated by intra-molecular interactions between its two domains, as well as inter-molecular interactions between Hsp70 and its co-chaperones.
Li, Xiaokai +3 more
openaire +4 more sources
Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates [PDF]
, 2017 The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in living systems, such as protecting cells against protein aggregation, assisting protein folding, remodeling protein complexes and driving the translocation into organelles.
Hartich, David +3 more
core +2 more sources
Expression of Heat Shock Protein 70 Is Insufficient To Extend Drosophila melanogaster Longevity
G3: Genes, Genomes, Genetics, 2019 It has been known for over 20 years that Drosophila melanogaster flies with twelve additional copies of the hsp70 gene encoding the 70 kD heat shock protein lives longer after a non-lethal heat treatment.
Chengfeng Xiao +7 more
doaj +1 more source
Heat shock protein and gene regulation in goats during heat stress
Indian Journal of Animal Sciences, 2021 Heat shock proteins (HSPs), also known as molecular chaperons are prominent stress markers. Heat shock proteins consist of highly conserved protein expressed at the time of stress, and play an important role in adaptation to the environmental stress ...
UMESH BABU CHAUDHARY +4 more
doaj +1 more source
PLoS ONE, 2015 Background The ubiquitous occurrence of inducible Heat Shock Proteins (Hsps) up-regulation in response to cold-acclimation and/or to cold shock, including massive increase of Hsp70 mRNA levels, often led to hasty interpretations of its role in the repair
T. Štětina +2 more
semanticscholar +1 more source
Binding of Heat-Shock Protein 70 (hsp70) to Tubulin
Archives of Biochemistry and Biophysics, 1994 Binding of heat-shock protein (hsp70) to polymerized tubulin has been investigated by in vitro experiments. The tubulin region involved in binding to hsp70 corresponds to the carboxy-terminal residues 431-444, also involved in the association with other microtubule-associated proteins (MAPs).
Sánchez, Carlos +4 more
openaire +3 more sources
Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target [PDF]
Journal of Medicinal Chemistry, 2010 Heat shock protein 70 (Hsp70) is a molecular chaperone that is expressed in response to stress. In this role, Hsp70 binds to its protein substrates and stabilize them against denaturation or aggregation until conditions improve.1 In addition to its functions during a stress response, Hsp70 has multiple responsibilities during normal growth; it assists ...
Christopher G, Evans +2 more
openaire +2 more sources
Serum Hsp70 antigen: Early diagnosis marker in perinatal asphyxia [PDF]
, 2015 BACKGROUND: Perinatal asphyxia is an important cause of mortality and permanent neurological and developmental deficit. Early and accurate diagnosis would help to establish the likely prognosis and may also help in determining the most appropriate ...
Boskabadi, Hassan +6 more
core +1 more source
Heat Shock Proteins (HSP70) as Biomarkers in Ecotoxicological Studies
Ecotoxicology and Environmental Safety, 1997 Hsp70, so-called stress proteins, were studied in the centipede Lithobius mutabilis when exposed in laboratory tests to different concentrations of the insecticide dimethoate (DMT; 0, 0.012, 0.111 mg kg-1 dwt), the detergent linear alkilobenzene sulfonate (LAS; 0, 16, 80, 400, 2000, 10,000 mg kg-1 dwt), and copper (Cu; 0, 56, 167, 500, 1000, 1500 mg kg-
Pyza, Elżbieta +3 more
openaire +3 more sources