Results 171 to 180 of about 138,190 (352)

Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers. [PDF]

, 2020
Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene.
de Oliveira, Guilherme AP, Ferretti, Giulia DS, Gratton, Enrico, Lima, Flavia RS, Motta, Michelle F, Norberto, Douglas R, Pedrote, Murilo M, Silva, Jerson L, Spohr, Tania CLS   +8 more
core   +1 more source

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Nature Communications, 2018
The molecular chaperone Hsp90 is critical for the maintenance of cellular homeostasis and represents a promising drug target. Despite increasing knowledge on the structure of Hsp90, the molecular basis of substrate recognition and pro-folding by Hsp90/co-
J. Oroz, Bliss J. Chang, Piotr Wysoczański, Chung-Tien Lee, Á. Pérez-Lara, Pijush Chakraborty, Romina V. Hofele, Jeremy D. Baker, Laura J. Blair, J. Biernat, H. Urlaub, E. Mandelkow, C. Dickey, M. Zweckstetter   +13 more
semanticscholar   +1 more source

High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex [PDF]

, 2013
Régis Back, Cyril Dominguez, Benjamin Rothé, Claude Bobo, Chrystel Beaufils, S. Moréra, Philippe Meyer, Bruno Charpentier, Christiane Branlant, Frédéric H.‐T. Allain, Xavier Manival   +10 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Hsp90 regulation of fibroblast activation in pulmonary fibrosis.

JCI Insight, 2017
Idiopathic pulmonary fibrosis (IPF) is a severe fibrotic lung disease associated with fibroblast activation that includes excessive proliferation, tissue invasiveness, myofibroblast transformation, and extracellular matrix (ECM) production.
Vishwaraj Sontake, Yunguan Wang, R. K. Kasam, D. Sinner, G. Reddy, A. Naren, F. McCormack, E. White, A. Jegga, S. Madala   +9 more
semanticscholar   +1 more source

Mass spectrometry‐based mitochondrial proteomics for cancer biomarker discovery

VIEW, EarlyView.
Figure.1 Schematic diagram of MS‐based mitochondrial proteomics for cancer biomarker discovery. The workflow highlights the integration of advanced technological platforms in mitochondrial proteomics and their application in cancer biomarker discovery.
Zheng Cao, ZiKun Song, Weijie Zhou, Xiaohui Liu, Yanling Liu, Peng R. Chen, Kun Qian   +6 more
wiley   +1 more source

Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism

Nature, 2021
C. Noddings, R. Wang, Jill L. Johnson, D. Agard   +3 more
semanticscholar   +1 more source

Data from Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas

, 2023
M. Nieves Calvo-Vidal, Nahuel Zamponi, Jan Krumsiek, Max A. Stockslager, María V. Revuelta, Jude M. Phillip, Rossella Marullo, Ekaterina N. Tikhonova, Nikita Kotlov, Jayeshkumar Patel, Shao Ning Yang, Lucy Yang, Tony Taldone, Catherine Thieblemont, John P. Leonard, P. G. Martin, Giorgio Inghirami, Gabriela Chiosis, Scott R. Manalis, Leandro Cerchietti   +19 more
openalex   +1 more source

Trematode infection buffers heat stress in blue mussels Mytilus edulis: The role of heat shock proteins

Journal of Animal Ecology, EarlyView.
The study shows that parasite infection changes heat shock protein expression and can increase heat tolerance in blue mussels. By separating parasite and temperature effects, the results suggest that infection may improve survival during heat stress, highlighting important parasite–host interactions for climate change resilience. Abstract The influence
Annika Greve, Jesper G. Sørensen, Mikael K. Sejr, Jakob Thyrring   +3 more
wiley   +1 more source

The Mechanism of Hsp90 ATPase Stimulation by Aha1 [PDF]

, 2016
Annemarie Wolmarans, Brian Lee, Leo Spyracopoulos, Paul LaPointe   +3 more
openalex   +1 more source