Results 31 to 40 of about 110,857 (299)
Tetraspanin CD81 regulates HSV-1 infection [PDF]
Medical Microbiology and Immunology, 2020 Different members of the tetraspanin superfamily have been described to regulate different virus infectious cycles at several stages: viral entry, viral replication or virion exit or infectivity. In addition, tetraspanin CD81 regulates HIV reverse transcription through its association with the dNTP hydrolase SAMHD1.
Beatriz Benayas +7 more
openaire +5 more sources
A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro [PDF]
, 2015 The ubiquitin–proteasome system is an essential cellular process that plays a fundamental role in the regulation of protein stability. This pathway is tightly controlled by a sequential cascade of enzymatic steps that culminates in the formation of a ...
Boutell, Chris, Davido, David J.
core +2 more sources
Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells [PDF]
, 2016 We have previously shown that clusters of guanine quadruplex (G4) structures can form in the human herpes simplex-1 (HSV-1) genome. Here we used immunofluorescence and immune-electron microscopy with a G4-specific monoclonal antibody to visualize G4 ...
Artusi, Sara +6 more
core +1 more source
HSV-1 glycoprotein endocytosis [PDF]
, 2015 Herpes simplex virus-1 (HSV-1) is a large enveloped DNA virus that belongs to the family of Herpesviridae. It has been recently shown that the cytoplasmic membranes that wrap the newly assembled capsids are endocytic compartments derived from the plasma ...
Albecka, Anna +4 more
core +6 more sources
LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. [PDF]
PLoS ONE, 2012 After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection.
Andrea S Bertke +8 more
doaj +1 more source
Genital HSV-1 infections [PDF]
Sexually Transmitted Infections, 2006 Importantly, individuals with genital HSV-1 are still at risk of HSV-2 acquisition In the past decade, investigations have amply documented the increase in the frequency of genital herpes simplex virus type 1 (HSV-1) compared with genital HSV-2 infection.
openaire +1 more source
Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis [PDF]
, 2005 Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable ...
Gonzalez, Maria Ines +5 more
core +1 more source
HSV neutralization by the microbicidal candidate C5A. [PDF]
PLoS ONE, 2011 Genital herpes is a major risk factor in acquiring human immunodeficiency virus type-1 (HIV-1) infection and is caused by both Herpes Simplex virus type 1 (HSV-1) and HSV-2.
Lot de Witte +6 more
doaj +1 more source
PLoS Pathogens, 2020 HSV-1 causes 50% of first-time genital herpes infections in resource-rich countries and affects 190 million people worldwide. A prophylactic herpes vaccine is needed to protect against genital infections by both HSV-1 and HSV-2. Previously our laboratory
Kevin P Egan +7 more
doaj +1 more source
Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons
Viruses, 2021 Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis.
Petra Bergström +13 more
doaj +1 more source