Results 41 to 50 of about 29,786,765 (312)

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection.

PLoS Pathogens, 2020
HSV-1 causes 50% of first-time genital herpes infections in resource-rich countries and affects 190 million people worldwide. A prophylactic herpes vaccine is needed to protect against genital infections by both HSV-1 and HSV-2. Previously our laboratory
Kevin P Egan, Lauren M Hook, Alexis Naughton, Norbert Pardi, Sita Awasthi, Gary H Cohen, Drew Weissman, Harvey M Friedman   +7 more
doaj   +1 more source

LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. [PDF]

PLoS ONE, 2012
After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection.
Andrea S Bertke, Kathleen Apakupakul, AyeAye Ma, Yumi Imai, Anne M Gussow, Kening Wang, Jeffrey I Cohen, David C Bloom, Todd P Margolis   +8 more
doaj   +1 more source

Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012.

PLoS ONE, 2015
BackgroundHerpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection.
Katharine J Looker, Amalia S Magaret, Margaret T May, Katherine M E Turner, Peter Vickerman, Sami L Gottlieb, Lori M Newman   +6 more
doaj   +1 more source

HSV-1 Neuroinvasiveness

Intervirology, 1993
Neuroinvasiveness, the capacity of virus to enter and progress through the nervous system, may be accomplished by hematogenous or neural routes. We have been interested in defining HSV-1 genes specifically concerned with the neural pathway. In one system (involving HSV strain Ang), we have found that a single amino acid change in glycoprotein D, a ...
openaire   +2 more sources

Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons

Viruses, 2021
Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis.
Petra Bergström, Edward Trybala, Charlotta E. Eriksson, Maria Johansson, Tugce Munise Satir, Sibylle Widéhn, Stefanie Fruhwürth, Wojciech Michno, Faisal Hayat Nazir, Jörg Hanrieder, Soren Riis Paludan, Lotta Agholme, Henrik Zetterberg, Tomas Bergström   +13 more
doaj   +1 more source

Herpes simplex virus assembly and spread in murine skin after infection from the outside

Journal of Virology
Herpes simplex viruses (HSV) cause many skin diseases, particularly in immunocompromised patients. HSV-1 infection of murine skin recapitulates many aspects of human pathology.
Timmy Richardo, Xiaokun Liu, Katinka Döhner, Tsung-Yu Chao, Anna Buch, Anne Binz, Anja Pohlmann, Madeleine de le Roi, Wolfgang Baumgärtner, Korbinian Brand, Rudolf Bauerfeind, Reinhold Förster, Beate Sodeik, Stephan Halle   +13 more
doaj   +1 more source

Anti-HSV-1 CRISPR gRNAs are ineffective in targeting quiescent HSV-1 but do abrogate replication of reactivated HSV-1.

, 2016
a) MRC5 cells exogenously expressing Cas9 were infected with quiescent HSV-1-eGFP. Anti-HSV-1 gRNAs were introduced into the MRC5-Cas9 cells via lentiviral transduction and cells were subsequently superinfected with HCMV to reactivate latent HSV-1.
Anita C. Schürch (173257), Saskia M. Imhof (2863670), Emmanuel J. H. J. Wiertz (124100), Ferdy R. van Diemen (2863673), Elisabeth M. Kruse (2863667), Robert Jan Lebbink (341442), Marjolein J. G. Hooykaas (2863664), Carlijn E. Bruggeling (2863676), Monique Nijhuis (89548), Petra M. van Ham (214475)   +9 more
core   +1 more source

The epidemiology of HIV and HSV-2 infections among women participating in microbicide and vaccine feasibility studies in Northern Tanzania. [PDF]

, 2013
OBJECTIVES: To prepare for future HIV prevention trials, we conducted prospective cohort studies among women working in food and recreational facilities in northern Tanzania.
Watson-Jones Deborah, Joseph Chilongani, Mongi Aika, Watson-Jones, Deborah, John Changalucha (243873), Hashim, Ramadhan, Tony Ao (434475), Hayes Richard, Saidi H. Kapiga (124370), Saidi H Kapiga, Aika Mongi, Aura Andreasen, Deborah Watson-Jones, Aika Mongi (434477), Kathy Baisley (132119), Ramadhan Hashim (148699), Deborah Watson-Jones (230055), Chilongani Joseph, Baisley, Kathy, Francis, Suzanna, Changalucha John, Fiona M. Ewings (309182), Hayes, Richard, Richard Hayes, Chilongani, Joseph, Kathy Baisley, Suzanna Francis, Richard Hayes (32740), Changalucha, John, Aura Andreasen (247728), Joseph Chilongani (434476), Kapiga, Saidi H, Ao, Tony, Mongi, Aika, Andreasen, Aura, Ramadhan Hashim, Andreasen Aura, John Changalucha, Hashim Ramadhan, Francis Suzanna, Ao Tony, Tony Ao, Baisley Kathy, Fiona M Ewings, Ewings Fiona M., Suzanna Francis (434478), Kapiga Saidi H., Ewings, Fiona M   +47 more
core   +1 more source

DataSheet1_Effective Search of Triterpenes with Anti-HSV-1 Activity Using a Classification Model by Logistic Regression.pdf

, 2021
Natural products are an excellent source of skeletons for medicinal seeds. Triterpenes and saponins are representative natural products that exhibit anti-herpes simplex virus type 1 (HSV-1) activity.
Keiko Ogawa (1796347), Kaori Ryu (11634619), Seikou Nakamura (1796341), Taichi Yoneda (8788058), Haruka Oguri (11634616), Rumiko Hosoki (11634622)   +5 more
core   +1 more source

Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

BMC Infectious Diseases, 2002
Background The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold
Leary Jeffry J, Halsey Wendy M, Bartus Joan O, Wittrock Robert J, Nguyen Tammy T, Quail Matthew R, Duffy Karen E, Bacon Teresa H, Sarisky Robert T   +8 more
doaj   +1 more source