Results 21 to 30 of about 84,858 (261)

Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia. [PDF]

PLoS Pathogens, 2013
Herpes simplex virus type 1 (HSV-1) infection results in lifelong chronic infection of trigeminal ganglion (TG) neurons, also referred to as neuronal HSV-1 latency, with periodic reactivation leading to recrudescent herpetic disease in some persons.
Monique van Velzen, Lichen Jing, Albert D M E Osterhaus, Alessandro Sette, David M Koelle, Georges M G M Verjans   +5 more
doaj   +1 more source

HSV-2- and HIV-1- permissive cell lines co-infected by HSV-2 and HIV-1 co-replicate HSV-2 and HIV-1 without production of HSV-2/HIV-1 pseudotype particles

Virology Journal, 2007
Background Herpes simplex virus type 2 (HSV-2) is a major cofactor of human immunodeficiency virus type 1 (HIV-1) sexual acquisition and transmission.
Bélec Laurent, Muggeridge Martin, Si-Mohamed Ali, Klein Christophe, Hocini Hakim, Lecerf Maxime, Bouhlal Hicham, LeGoff Jérôme   +7 more
doaj   +1 more source

HSV neutralization by the microbicidal candidate C5A. [PDF]

PLoS ONE, 2011
Genital herpes is a major risk factor in acquiring human immunodeficiency virus type-1 (HIV-1) infection and is caused by both Herpes Simplex virus type 1 (HSV-1) and HSV-2.
Lot de Witte, Michael D Bobardt, Udayan Chatterji, Freek B van Loenen, Georges M G M Verjans, Teunis B H Geijtenbeek, Philippe A Gallay   +6 more
doaj   +1 more source

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection.

PLoS Pathogens, 2020
HSV-1 causes 50% of first-time genital herpes infections in resource-rich countries and affects 190 million people worldwide. A prophylactic herpes vaccine is needed to protect against genital infections by both HSV-1 and HSV-2. Previously our laboratory
Kevin P Egan, Lauren M Hook, Alexis Naughton, Norbert Pardi, Sita Awasthi, Gary H Cohen, Drew Weissman, Harvey M Friedman   +7 more
doaj   +1 more source

LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. [PDF]

PLoS ONE, 2012
After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection.
Andrea S Bertke, Kathleen Apakupakul, AyeAye Ma, Yumi Imai, Anne M Gussow, Kening Wang, Jeffrey I Cohen, David C Bloom, Todd P Margolis   +8 more
doaj   +1 more source

HSV-1 Neuroinvasiveness

Intervirology, 1993
Neuroinvasiveness, the capacity of virus to enter and progress through the nervous system, may be accomplished by hematogenous or neural routes. We have been interested in defining HSV-1 genes specifically concerned with the neural pathway. In one system (involving HSV strain Ang), we have found that a single amino acid change in glycoprotein D, a ...
openaire   +2 more sources

Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012.

PLoS ONE, 2015
BackgroundHerpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection.
Katharine J Looker, Amalia S Magaret, Margaret T May, Katherine M E Turner, Peter Vickerman, Sami L Gottlieb, Lori M Newman   +6 more
doaj   +1 more source

Herpes simplex virus assembly and spread in murine skin after infection from the outside

Journal of Virology
Herpes simplex viruses (HSV) cause many skin diseases, particularly in immunocompromised patients. HSV-1 infection of murine skin recapitulates many aspects of human pathology.
Timmy Richardo, Xiaokun Liu, Katinka Döhner, Tsung-Yu Chao, Anna Buch, Anne Binz, Anja Pohlmann, Madeleine de le Roi, Wolfgang Baumgärtner, Korbinian Brand, Rudolf Bauerfeind, Reinhold Förster, Beate Sodeik, Stephan Halle   +13 more
doaj   +1 more source

Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

BMC Infectious Diseases, 2002
Background The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold
Leary Jeffry J, Halsey Wendy M, Bartus Joan O, Wittrock Robert J, Nguyen Tammy T, Quail Matthew R, Duffy Karen E, Bacon Teresa H, Sarisky Robert T   +8 more
doaj   +1 more source

Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons

Viruses, 2021
Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis.
Petra Bergström, Edward Trybala, Charlotta E. Eriksson, Maria Johansson, Tugce Munise Satir, Sibylle Widéhn, Stefanie Fruhwürth, Wojciech Michno, Faisal Hayat Nazir, Jörg Hanrieder, Soren Riis Paludan, Lotta Agholme, Henrik Zetterberg, Tomas Bergström   +13 more
doaj   +1 more source