Results 81 to 90 of about 177,583 (277)
Frontiers in ImmunologyIntroductionHead and neck cancer (HNC) is a complex disease, and multiple risk factors can lead to its progression. Observational studies indicated that herpes simplex virus (HSV) may be correlated with the risk of HNC.
Ming Yan +10 more
doaj +1 more source
Measurement and predictors of adherence in a trial of HSV suppressive therapy in Tanzania.
, 2009 This study estimates adherence and identifies predictors of good adherence among 1305 Tanzanian women participating in a randomised, double-blind, placebo-controlled trial of HSV suppressive therapy to reduce HIV incidence or genital HIV shedding.
Baisley, Kathy +10 more
core +1 more source
"Virus hunting" using radial distance weighted discrimination [PDF]
, 2015 Motivated by the challenge of using DNA-seq data to identify viruses in human blood samples, we propose a novel classification algorithm called "Radial Distance Weighted Discrimination" (or Radial DWD).
Dittmer, D. P. +2 more
core +3 more sources
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Pifu-xingbing zhenliaoxue zazhiHerpes simplex virus (HSV) types 1 and 2 pose significant health risks during pregnancy, impacting both maternal and neonatal outcomes. The 2024 joint guideline from the British Association for Sexual Health and HIV (BASHH) and the Royal College of ...
FERREIRA Esmeraldito +2 more
doaj +1 more source
Anti-Herpes Effect and Mode of Action of Hesperidin as a Safe and Promising Alternative Antiviral [PDF]
Journal of Bioscience and Applied ResearchGenital ulcer disease is most commonly caused by types I and II of the herpes simplex virus (HSV). These viruses also cause infections of the genitalia. To evaluate the prevalence of HSV infection in Egypt and its treatment with hesperidin extract, this ...
Mohammed Alhemaly +3 more
doaj +1 more source
pH Dependence and Stoichiometry of Binding to the Fc Region of IgG by the Herpes Simplex Virus Fc Receptor gE-gI [PDF]
, 2004 Herpes simplex virus type 1 encodes two glycoproteins, gE and gI, that form a heterodimer on the surface of virions and infected cells. The gE-gI heterodimer has been implicated in cell-to-cell spread of virus and is a receptor for the Fc fragment of IgG.
Bjorkman, Pamela J. +2 more
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Packing and Padding: Coupled Multi-index for Accurate Image Retrieval [PDF]
, 2014 In Bag-of-Words (BoW) based image retrieval, the SIFT visual word has a low discriminative power, so false positive matches occur prevalently. Apart from the information loss during quantization, another cause is that the SIFT feature only describes the ...
Liu, Ziqiong +3 more
core +3 more sources
Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation
Advanced Science, EarlyView.PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang +9 more
wiley +1 more source