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Visceral signaling of post-ingestive malaise directs memory updating in Drosophila

Senapati B, Treiber CD, Waddell S.
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Biosynthesis and preparation of T-2 Toxin, HT-2 Toxin and Neosolantol

Mycotoxin Research, 1987
Biosynthesis of trichothecenes by strains ofF. sporotriahioides KF 9 6 and KF 530 was performed on rice as a medium. Three toxins in significant amounts were produced, with yield: T-2 toxin 0.7g from 600g of drv culture, being the highest of the three metabolites, HT-2 toxin 0.06g an Neosolaniol 0.015g.
M, Kostecki, H, Jeleń, P, Gliński, J, Chełkowski   +3 more
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Inhibition of bovine platelet function by T-2 toxin, HT-2 toxin, diacetoxyscirpenol and deoxynivalenol

Food and Chemical Toxicology, 1984
The aggregation of bovine platelets suspended in homologous plasma is inhibited in the presence of T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) or deoxynivalenol (DON) when either collagen or ADP is used as the stimulatory agent for aggregation. For each of the mycotoxins the degree of inhibition is dependent on the amount of trichothecene present ...
P K, Chan, P A, Gentry
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Pharmacokinetics and protein binding of trichothecene mycotoxins, T-2 toxin and HT-2 toxin, in dogs

Toxicon, 1988
The pharmacokinetics of T-2 toxin, following i.m. and i.v. administration (0.4 mg/kg), were investigated in five dogs. Following i.m. administration, the mean pharmacokinetic parameters for T-2 and HT-2 toxins were, respectively: apparent half-life 21 +/- 5 and 73 +/- 7 min; peak plasma concentration 182 +/- 42 and 74 +/- 16 ng/ml; time to reach peak ...
A, Sintov, M, Bialer, B, Yagen
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Selenium promotes metabolic conversion of T-2 toxin to HT-2 toxin in cultured human chondrocytes

Journal of Trace Elements in Medicine and Biology, 2017
To explore the metabolism of T-2 toxin in human chondrocytes (HCs) and determine the impact of selenium supplementation. For determination of cytotoxicity using the MTT assay, optical density values were read with an automatic enzyme-linked immunosorbent assay reader at 510nm. Cell survival was calculated and the cytotoxicity estimated. To identify the
Fang-Fang, Yu, Xia-Lu, Lin, Xi, Wang, Huan, Liu, Lei, Yang, Mary B, Goldring, Mikko J, Lammi, Xiong, Guo   +7 more
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HPLC: A Tool for the Analysis of T-2 Toxin and HT-2 Toxin in Cereals

Journal of Analytical Toxicology, 1984
An analytical procedure for the determination of trichothecenes in various cereals is described. HPLC was performed with a reversed-phase (C18) column eluted with methanol:water (60:40, v/v). Compounds were detected with a refractive index detector. The elution patterns of free and contaminated samples were compared.
R, Schmidt, K, Dose
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The occurrence of HT-2 toxin and other trichothecenes in Norwegian cereals

Mycopathologia, 1999
A total of 449 grain samples, 102 barley, 169 wheat and 178 oat samples were collected from different regions of Norway from 1996-1998 crops, mainly from grain loads and silos. The samples were analysed for type A and B trichothecenes, the largest groups of mycotoxins produced by the Fusarium species, by gas chromatography with mass spectrometric ...
W, Langseth, T, Rundberget
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Chemical interconversion of T-2 and HT-2 toxins and related compounds

Biochemical and Biophysical Research Communications, 1971
Abstract Mild alkaline hydrolysis of 3α-hydroxy-4β, 15-diacetoxy-8α-isovaleroxy-12,13-epoxytrichothec-9-ene (T-2 toxin) gave the 3α,4β-diol (HT-2 toxin) and the 3α,4β,15-triol as well as the 3α,4β,8α,15-tetraol. Partial acetylation of the diol gave mainly the 4β-hydroxy-3α-acetate, isomeric with T-2 toxin.
R, Wei, F M, Strong, E B, Smalley, H K, Schnoes   +3 more
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