Results 201 to 210 of about 42,636 (233)

hTERT promoter methylation in pituitary adenomas

Brain Tumor Pathology, 2015
Telomerase reverse transcriptase (TERT) expression is a hallmark in tumorigenesis and upregulated due to mutations and methylation of the human (h)TERT promoter. As mutations are rare but methylation is common in pituitary adenomas (PA), we determined promoter methylation and its clinical impact in 85 primary and 15 recurrent PA by methylation-specific
Köchling M, Ewelt C, Fürtjes G, Peetz-Dienhart S, Koos B, Hasselblatt M, Paulus W, Stummer W, Brokinkel B   +8 more
openaire   +3 more sources

PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells

Tissue and Cell, 2010
We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased ...
Jian-Fei, Sheng, Wei, Chen, Yan, Yu, Jun, Liu, Ze-Zhang, Tao   +4 more
openaire   +2 more sources

Abstract C88: HPV infections, hTERT methylation and hTERT expression in patients with invasive cervical cancer

Molecular Cancer Therapeutics, 2015
Abstract Background: There is limited information of the role of hTERT methylation, hTERT expression and their association with type specific HPV infections in patients with invasive cervical cancer Objective: To analyze the possible association between methylation status of the hTERT promoter gene, hTERT expression and ...
Pablo Moreno-Acosta, Nicolas Morales, Marcela Burgos, Oscar Gamboa, Juan Carlos Mejia, Alfredo Romero-Rojas, Alba Lucia Combita, Monica Molano   +7 more
openaire   +1 more source

Alternative splicing of hTERT: a further mechanism for the control of active hTERT in acute myeloid leukemia

Leukemia & Lymphoma, 2017
hTERT component is the key regulator of telomerase. Alternatively spliced variants of hTERT generate different telomerase activity. The goal of the study was to determine the role of different hTERT isoforms in the regulation of telomerase expression in AML patients.
Calvello, Celeste, Rocca, Barbara, Klersy, Catherine, Zappatore, Rita, Giardini, Ilaria, Dambruoso, Irene, Pasi, Francesca, Caresana, Marilena, Zappasodi, Patrizia, Boni, Marina, NANO, ROSANNA, BERNASCONI, PAOLO   +11 more
openaire   +3 more sources

Abstract 4328: hTERT protein expression, hTERT methylation and HPV infection in uterine cervical cancer

Cancer Research, 2018
Abstract The analysis of expression of the hTERT protein, the methylation status of the hTERT gene as the type of HPV infection, will contribute to deepen the role played by HPV infection in the expression and methylation of hTERT. The study included a group of one hundred fifty-five samples of women with squamous cell carcinomas of the ...
Pablo Moreno-Acosta, Mónica Molano, Nicolas Morales, Alfredo Romero-Rojas, Oscar Gamboa, Jinneth Acosta, Raynner Alvarez, Nicolas Magné, Nubia Muñoz   +8 more
openaire   +1 more source

Evaluation of telomerase mRNA (hTERT) in colon cancer

International Journal of Oncology, 2002
Telomerase activation, a cardinal requirement for immortalization, is a crucial step in the development of malignancy and requires the induction of the catalytic component, human telomerase reverse transcriptase (hTERT), encoded by the hTERT gene.
BOLDRINI, LAURA, FAVIANA, PINUCCIA, GISFREDI S, ZUCCONI Y, DI QUIRICO D, DONATI V, BERTI, PIERO, SPISNI, ROBERTO, GALLERI D, MATERAZZI, GABRIELE, BASOLO, FULVIO, MICCOLI, PAOLO, PINGITORE, RAFFAELE, FONTANINI, GABRIELLA   +13 more
openaire   +3 more sources

Characterization of hTERT‐Immortalized Caprine Mammary Epithelial Cells

Reproduction in Domestic Animals, 2011
ContentsThe aim of this article is to demonstrate and characterize caprine mammary epithelial cells (CMC) immortalized with human telomerase reverse transcriptase (hTERT) gene. Five immortalized CMCs were assigned to either myoepithelial or luminal epithelial groups based on their morphology and expression of cell lineage‐specific intermediate ...
M W, Ke, J T, Hsu, Y N, Jiang, W T K, Cheng, Y T, Ju   +4 more
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hTERTmethylation and expression in gastric cancer

Biomarkers, 2009
Gastric cancer is the second most prevalent cause of cancer death worldwide. DNA methylation is a common event in gastric carcinogenesis. hTERT seems to be the rate-limiting determinant of telomerase activation, which is responsible for stability and life span. hTERT hypermethylation has been associated with telomerase expression. In the present study,
Carolina Oliveira, Gigek, Mariana Ferreira, Leal, Patricia Natalia Oliveira, Silva, Luara Carolina Frias, Lisboa, Eleonidas Moura, Lima, Danielle Queiroz, Calcagno, Paulo Pimentel, Assumpção, Rommel Rodriguez, Burbano, Marilia de Arruda Cardoso, Smith   +8 more
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[Proliferation and hTERT expression in neuroblastoma].

Der Pathologe, 2004
Transcription of the catalytic subunit of telomerase, human Telomerase Reverse Transcriptase (hTERT), and increased tumor cell proliferation are powerful prognostic factors in neuroblastoma. We therefore investigated their relationship in a large group of neuroblastomas.RT-PCR analysis was used to discriminate between the various hTERT transcripts ...
M, Krams, P, Rudolph, D, Harms
openaire   +1 more source

Alternative splicing is a developmental switch for hTERT expression

Molecular Cell, 2021
Michael J Shen, Jef D Boeke, Sharon A Savage   +2 more
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