Results 211 to 220 of about 28,110 (249)

hTERT genetic variation in depression

Journal of Affective Disorders, 2016
Telomeres are protective DNA-protein complexes forming the chromosome ends. TL differs between tissues. Shorter telomere length (TL) in blood leukocytes (LTL) has been associated with major depression, and with previous exposure to childhood adversity. TL studies on non-invasively sampled salivary DNA are less common.
Ya Bin, Wei, Lina, Martinsson, Jia Jia, Liu, Yvonne, Forsell, Martin, Schalling, Lena, Backlund, Catharina, Lavebratt   +6 more
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Acute Exercise Regulates hTERT Gene Expression and Alternative Splicing in the hTERT-BAC Transgenic Mouse Model

Medicine & Science in Sports & Exercise, 2022
ABSTRACT Introduction Aerobic exercise maintains telomere length through increased human telomerase reverse transcriptase (hTERT) expression and telomerase enzyme activity. The impact of acute exercise on hTERT alternative splicing (AS) is unknown. Purpose This study aimed
Aaron L, Slusher, Jeongjin Jj, Kim, Mark, Ribick, Andrew T, Ludlow   +3 more
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Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT

Journal of Bioscience and Bioengineering, 2015
Cordycepin is an adenosine analog originally extracted from Cordyceps militaris that possesses many pharmacological effects including immune activation and antioxidant and antitumor effects. However, the underlying relationship between apoptosis and telomerase activity in response to cordycepin exposure has not been investigated.
Kyung-Jun, Jang, Gi-Sun, Kwon, Jin-Woo, Jeong, Cheol-Hong, Kim, Hyun-Min, Yoon, Gi-Young, Kim, Jung-Hyun, Shim, Sung-Kwon, Moon, Wun-Jae, Kim, Yung Hyun, Choi   +9 more
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Alternative splicing of hTERT: a further mechanism for the control of active hTERT in acute myeloid leukemia

Leukemia & Lymphoma, 2017
hTERT component is the key regulator of telomerase. Alternatively spliced variants of hTERT generate different telomerase activity. The goal of the study was to determine the role of different hTERT isoforms in the regulation of telomerase expression in AML patients.
Calvello, Celeste, Rocca, Barbara, Klersy, Catherine, Zappatore, Rita, Giardini, Ilaria, Dambruoso, Irene, Pasi, Francesca, Caresana, Marilena, Zappasodi, Patrizia, Boni, Marina, NANO, ROSANNA, BERNASCONI, PAOLO   +11 more
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hTERT promoter methylation in pituitary adenomas

Brain Tumor Pathology, 2015
Telomerase reverse transcriptase (TERT) expression is a hallmark in tumorigenesis and upregulated due to mutations and methylation of the human (h)TERT promoter. As mutations are rare but methylation is common in pituitary adenomas (PA), we determined promoter methylation and its clinical impact in 85 primary and 15 recurrent PA by methylation-specific
Köchling M, Ewelt C, Fürtjes G, Peetz-Dienhart S, Koos B, Hasselblatt M, Paulus W, Stummer W, Brokinkel B   +8 more
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hTERT: Another brick in the wall of cancer cells

Mutation Research/Reviews in Mutation Research, 2013
In human cancer, expression of telomerase is positively correlated with tumour aggressiveness and metastatic potential. There is accumulating evidence that hTERT (the catalytic subunit of telomerase) favours an immortal phenotype by blocking programmed cell death (apoptosis) independently of its protective function at the telomere ends.
Lamy, Evelyn, Goetz, Victoria, Erlacher, Miriam, Herz, Corinna, Mersch-Sundermann, Volker   +4 more
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Coronary artery disease and a functional polymorphism of hTERT

Biochemical and Biophysical Research Communications, 2006
Genetic variation, a -1327T/C polymorphism, of human telomerase reverse transcriptase (hTERT) is associated with leukocyte telomere length in healthy subjects, but clinical significances of this functional polymorphism are not clear. Recently, the relationship between the telomere system and coronary artery disease (CAD) was reported.
Yumiko, Matsubara, Mitsuru, Murata, Kiyoaki, Watanabe, Ikuo, Saito, Koichi, Miyaki, Kazuyuki, Omae, Mie, Ishikawa, Kenichi, Matsushita, Shiro, Iwanaga, Satoshi, Ogawa, Yasuo, Ikeda   +10 more
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PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells

Tissue and Cell, 2010
We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased ...
Jian-Fei, Sheng, Wei, Chen, Yan, Yu, Jun, Liu, Ze-Zhang, Tao   +4 more
openaire   +2 more sources

Expression of hTERT, p53 and PCNA in cystitis glandularis

Journal of Huazhong University of Science and Technology, 2007
To examine the expression of human telomere reverse transcriptase (hTERT), p53 and proliferating cell nuclear antigen (PCNA) in cystitis glandularis, 38 patients were divided into two groups: group A (including 18 cases of papillary cystitis glandularis) and group B (including 20 subjects with normal bladder mucosa).
Zhifeng, Wei, Zhangqun, Ye, Zhiqiang, Chen   +2 more
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Evaluation of telomerase mRNA (hTERT) in colon cancer

International Journal of Oncology, 2002
Telomerase activation, a cardinal requirement for immortalization, is a crucial step in the development of malignancy and requires the induction of the catalytic component, human telomerase reverse transcriptase (hTERT), encoded by the hTERT gene.
BOLDRINI, LAURA, FAVIANA, PINUCCIA, GISFREDI S, ZUCCONI Y, DI QUIRICO D, DONATI V, BERTI, PIERO, SPISNI, ROBERTO, GALLERI D, MATERAZZI, GABRIELE, BASOLO, FULVIO, MICCOLI, PAOLO, PINGITORE, RAFFAELE, FONTANINI, GABRIELLA   +13 more
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