Results 1 to 10 of about 262,854 (112)
A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics [PDF]
Frontiers in Cell and Developmental Biology, 2021 Myasthenia gravis (MG) is a chronic and progressive neuromuscular disease where autoantibodies target essential proteins such as the nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction (NMJ) causing muscle fatigue and weakness ...
Virginia M. Smith +7 more
doaj +5 more sources
A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation [PDF]
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020 Introduction The quest to identify an effective therapeutic strategy for neurodegenerative diseases, such as mild congitive impairment (MCI) and Alzheimer's disease (AD), suffers from the lack of good human‐based models. Animals represent the most common
Julbert Caneus +10 more
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Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies. [PDF]
Adv Ther (Weinh), 2022 AbstractChronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here the authors describe a phenotypic, human‐on‐a‐chip (HoaC) electrical conduction model of two rare autoimmune demyelinating neuropathies, chronic inflammatory demyelinating polyneuropathy (CIDP) and ...
Rumsey JW +21 more
europepmc +3 more sources
Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation. [PDF]
Sci Rep, 2021 AbstractNonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly correlates with the growing incidence of obesity and type II diabetes. We have developed a human-on-a-chip model composed of human hepatocytes and adipose tissue chambers capable of modeling the metabolic factors that contribute to liver disease development ...
Slaughter VL +10 more
europepmc +5 more sources
A human-on-a-chip approach to tackling rare diseases. [PDF]
Drug Discov Today, 2019 Drug development for rare diseases, classified as diseases with a prevalence of < 200 000 patients, is limited by the high cost of research and low target population. Owing to a lack of representative disease models, research has been challenging for orphan drugs.
de Mello CPP +3 more
europepmc +4 more sources
Circadian hormone control in a human-on-a-chip: In vitro biology's ignored component? [PDF]
Exp Biol Med (Maywood), 2017 Organs-on-Chips (OoCs) are poised to reshape dramatically the study of biology by replicating in vivo the function of individual and coupled human organs. Such microphysiological systems (MPS) have already recreated complex physiological responses necessary to simulate human organ function not evident in two-dimensional in vitro biological experiments.
Cyr KJ, Avaldi OM, Wikswo JP.
europepmc +4 more sources
Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System. [PDF]
Adv Funct Mater, 2019 AbstractThe goal of human‐on‐a‐chip systems is to capture multiorgan complexity and predict the human response to compounds within physiologically relevant platforms. The generation and characterization of such systems is currently a focal point of research given the long‐standing inadequacies of conventional techniques for predicting human outcome ...
Oleaga C +20 more
europepmc +3 more sources
Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. [PDF]
Biomaterials, 2018 Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully represent physiology, often lacking xenobiotic metabolism. Functional human multi-organ systems containing iPSC derived cardiomyocytes and primary hepatocytes were ...
Oleaga C +23 more
europepmc +5 more sources
Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment [PDF]
Trends in Food Science & Technology, 2016 Equipment and device qualification and test assay validation in the field of tissue engineered human organs for substance assessment remain formidable tasks with only a few successful examples so far. The hurdles seem to increase with the growing complexity of the biological systems, emulated by the respective models.
Sofia P, Rebelo +5 more
+6 more sources
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introdução: Modelos com maior capacidade preditiva e que produzam resultados a custos mais baixos e em prazos menores são necessários para o desenvolvimento de fármacos. Os sistemas microfisiológicos (SMF) que cultivam tecidos humanos em histoarquitetura
Talita Miguel Marin, Eduardo Pagani
doaj +7 more sources