Results 11 to 20 of about 263,329 (257)
Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Biosensors, 2023 The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs.
Dimple Palanilkunnathil Thomas +3 more
doaj +1 more source
Organ-On-A-Chip: An Emerging Research Platform
Organogenesis, 2023 In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology.
Nithin R +4 more
doaj +1 more source
Frontiers in Toxicology, 2022 Investigating systemic toxicity in vitro is still a huge challenge. Here, a multi-organ-on-chip approach is presented as a typical case of topical exposure of oral mucosa to metals, which are known to activate the immune system and in turn may result in ...
Jasper J. Koning +8 more
doaj +1 more source
Human Nonalcoholic Steatohepatitis on a Chip
Hepatology Communications, 2021 Nonalcoholic steatohepatitis (NASH), an advanced stage of nonalcoholic fatty liver disease (NAFLD), is a rapidly growing and global health problem compounded by the current absence of specific treatments. A major limiting factor in the development of new
May S. Freag +5 more
doaj +1 more source
On being the right size: scaling effects in designing a human-on-a-chip [PDF]
Integrative Biology, 2013 Developing a human-on-a-chip by connecting multiple model organ systems would provide an intermediate screen for therapeutic efficacy and toxic side effects of drugs prior to conducting expensive clinical trials. However, correctly designing individual organs and scaling them relative to each other to make a functional microscale human analog is ...
Moraes, Christopher +5 more
openaire +3 more sources
Multi-scale cellular engineering: From molecules to organ-on-a-chip. [PDF]
, 2020 Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems.
Cahan, Patrick +8 more
core +2 more sources
Materials & Design, 2018 The non-ionic surfactant, Tween 80 (T80) a material with promising applications in the pharmaceutical, cosmetic, and food industries, has been explored here for the design of novel nanostructures (NS).
Dickson Joseph +3 more
doaj +1 more source
A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow [PDF]
, 2016 © 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology ...
A. Dawson +11 more
core +1 more source
Mechano-transduction: from molecules to tissues. [PDF]
, 2014 External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R +3 more
core +2 more sources
Integrating biological vasculature into a multi-organ-chip microsystem [PDF]
, 2013 Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Brincker, Sven +12 more
core +2 more sources