Marine Drugs, 2018 Current trends in the application of nanomaterials are emerging in the nano-biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) are photosynthetic prokaryotes that have applications to human health and numerous ...
Vivek K. Bajpai +6 more
doaj +1 more source
Cystic Fibrosis Human Organs-on-a-Chip
Micromachines, 2021 Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most ...
Herbert Luke Ogden +4 more
doaj +1 more source
Approaches to in vitro tissue regeneration with application for human disease modeling and drug development [PDF]
, 2014 Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations.
Borenstein, Jeffrey T. +4 more
core +1 more source
Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment [PDF]
, 2016 Organs-on-chips are three-dimensional, microfluidic cell culture systems that simulate the function of tissues and organ subunits. Organ-on-chip systems are expected to contribute to drug candidate screening and the reduction of animal tests in ...
Hummel, J. Marjan +6 more
core +8 more sources
Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans [PDF]
, 2015 Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults.
Bakan, Ahmet +14 more
core +1 more source
Maximizing the Impact of Microphysiological Systems with in Vitro–in Vivo Translation [PDF]
, 2018 Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here,
Cirit, Murat, Stokes, Cynthia L.
core +1 more source
A systematic review with narrative synthesis on medical robotics and laboratory automation in the control of SARS-CoV-2, Ebola and H1N1 (Swine Flu) viruses [PDF]
Journal of Health and Social Sciences, 2020 Introduction: Medical robotics is a rapidly growing aspect of the modern health care landscape. The aim of this paper was to review the availability of robotic technology and laboratory automation in the control of SARS-CoV-2, Ebola and H1N1 (Swine Flu ...
Shantani KANNAN +3 more
doaj +1 more source
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]
, 2018 Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
Brij M. Bhushan +37 more
core +2 more sources
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
core +1 more source
The method to generate pulsatile circulatory fluid flow using microfluidics
MethodsX, 2021 Microfluidic chips provide versatile tools to mimic the biological effect of blood flow on pluripotent stem cells (PSC). This paper presents methods for the use of microfluidics to model embryonic circulation using differentiated PSC.
Jingjing Li +2 more
doaj +1 more source