Chip-based human liver-intestine and liver-skin co-culture : A first step toward systemic repeated dose substance testing in vitro [PDF]
, 2015 Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives.
Ayehunie, Seyoum +12 more
core +1 more source
An innovative phase 2 proof-of-concept trial design to evaluate SAR445088, a monoclonal antibody targeting complement C1s in chronic inflammatory demyelinating polyneuropathy [PDF]
, 2023 Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated disease of the peripheral nerves, with significant unmet treatment needs. Clinical trials in CIDP are challenging; thus, new trial designs are needed. We present design of
Alonso-Alonso, Miguel +9 more
core +5 more sources
Revolutionizing nephrology research: expanding horizons with kidney-on-a-chip and beyond
Frontiers in Bioengineering and BiotechnologyOrgans-on-a-chip (OoC) is a microengineered three-dimensional cell culture system developed for decades. Utilizing microfluidic technology, OoC cultivates cells on perfusable channels to construct in vitro organ models, enabling the simulation of organ ...
Wei Huang +3 more
doaj +1 more source
Microorganisms, 2020 Pneumonia is the leading cause of hospitalization worldwide. Besides viruses, bacterial co-infections dramatically exacerbate infection. In general, surfactant protein-A (SP-A) represents a first line of immune defense. In this study, we analyzed whether
Elisabeth Schicke +17 more
doaj +1 more source
Towards establishing human body-on-a-chip systems
Stem Cell Research & Therapy, 2022 Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj +1 more source
Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices [PDF]
, 2021 Microfluidic ‘organ-on-a-chip’ devices hold great potential for better mimicking the continuous flow microenvironment experienced by tissue and cells in vivo, thereby ensuring realistic transport of nutrients and elimination of waste products.
Cawthorne, Chris +4 more
core +2 more sources
A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine [PDF]
, 2019 A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in
Ball, Graeme +7 more
core +4 more sources
A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications
BiosensorsOrgan-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost +1 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Microengineered systems provide an in vitro strategy to explore the variability of individual patient response to tissue engineering products, since they prefer the use of primary cell sources representing the phenotype variability.
Gabriele Nasello +6 more
doaj +1 more source
Microfabricated Physiological Models for In Vitro Drug Screening Applications [PDF]
, 2016 Microfluidics and microfabrication have recently been established as promising tools for developing a new generation of in vitro cell culture microdevices.
Cruz Moreira, Catia Daniela +4 more
core +2 more sources