Results 51 to 60 of about 263,329 (257)
A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
Micromachines, 2021 Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses.
Yasmin Roye +5 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Mimicking the kidney: A key role in organ-on-chip development [PDF]
, 2017 Pharmaceutical drug screening and research into diseases call for significant improvement in the effectiveness of current in vitro models. Better models would reduce the likelihood of costly failures at later drug development stages, while limiting or ...
Paoli, Roberto, Samitier i Martí, Josep
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems [PDF]
, 2015 Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation.
Cirit, Murat +2 more
core +1 more source
3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review [PDF]
, 2021 Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell ...
Carvalho, Violeta Meneses +9 more
core +1 more source
HIV Biosensors - The Potential of the Electrochemical Way
International Journal of Electrochemical Science, 2014 Because of high costs and time consuming common HIV tests, new ways in diagnosis, offering rapid, cheap, and accuracy possibility are looking for. One of the most promising fields is electrochemistry, providing very good specifity, relatively low price ...
Miguel Angel Merlos Rodrigo +6 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Industrial lab-on-a-chip: Design applications and scale-up for drug discovery and delivery [PDF]
, 2013 journal ...
ICHIKAWA Sosaku +7 more
core +1 more source
Journal of Biological Engineering, 2019 Background Exposure to air particulate matter (PM) is associated with various diseases in the human respiratory system. To date, most in vitro studies showing cellular responses to PM have been performed in cell culture using a single cell type.
Junhyoung Byun +11 more
doaj +1 more source