Results 71 to 80 of about 263,329 (257)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies [PDF]

, 2017
Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose.
Chen, Wen Li, Cirit, Murat, Edington, Collin D, Griffith, Linda G, Stokes, Cynthia L, Tsamandouras, Nikolaos   +5 more
core   +2 more sources

The Adoption and Adaption of Open Innovation: Empirical Evidence from the Biotechnology Industry [PDF]

, 2020
The biotechnology sector is one of the most research and development intensive sectors in the healthcare industry. This thesis provides insights into the innovation management approaches and underlying processes to develop radical innovative technologies,
Kunz, R., Kunz, R.
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism [PDF]

, 2014
Intelligent in vitro models able to recapitulate the physiological interactions between tissues in the body have enormous potential as they enable detailed studies on specific two-way or higher order tissue communication.
Arti Ahluwalia, Nadia Ucciferri, Tommaso Sbrana   +2 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. [PDF]

, 2014
Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment; and (iii) increase our understanding of
Alépée, N., Bahinski, A., Daneshian, M., De Wever, B., Fritsche, E., Goldberg, A., Hansmann, J., Hartung, T., Haycock, J., Hoelting, L., Hogberg, H., Kadereit, S., Kelm, J.M., Landsiedel, R., Leist, M., Lübberstedt, M., McVey, E., Noor, F., Pellevoisin, C., Petersohn, D., Pfannenbecker, U., Ramirez, T., Reisinger, K., Rothen-Rutishauser, B., Schäfer-Korting, M., Zeilinger, K., Zurich, M.G.   +26 more
core   +3 more sources

Pericytes repair engineered defects in the basement membrane to restore barrier integrity in an in vitro model of the blood-brain barrier

Materials Today Bio
Pericytes play a key role in the brain where they support brain microvascular endothelial cells (BMECs) in forming the tightly regulated blood-brain barrier (BBB).
Michelle A. Trempel, Yimei Du, Louis P. Widom, Emily E. Reitz, Alexis M. Feidler, Pelin Kasap, Britta Engelhardt, Thomas R. Gaborski, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +10 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies [PDF]

, 2018
This paper presents the design and fabrication of a multi-layer and multi-chamber microchip system using thiol-ene 'click chemistry' aimed for drug transport studies across tissue barrier models. The fabrication process enables rapid prototyping of multi-
Andresen, Thomas Lars, Dufva, Martin, Kutter, Jörg Peter, Rahbek, Ulrik L, Tan, Hsih-Yin, Trier, Sofie   +5 more
core   +3 more sources