Results 71 to 80 of about 266,906 (256)
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies [PDF]
, 2017 Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose.
Chen, Wen Li +5 more
core +2 more sources
The Adoption and Adaption of Open Innovation: Empirical Evidence from the Biotechnology Industry [PDF]
, 2020 The biotechnology sector is one of the most research and development intensive sectors in the healthcare industry. This thesis provides insights into the innovation management approaches and underlying processes to develop radical innovative technologies,
Kunz, R., Kunz, R.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism [PDF]
, 2014 Intelligent in vitro models able to recapitulate the physiological interactions between tissues in the body have enormous potential as they enable detailed studies on specific two-way or higher order tissue communication.
Arti Ahluwalia +2 more
core +2 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. [PDF]
, 2014 Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment; and (iii) increase our understanding of
Alépée, N. +26 more
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Materials Today BioPericytes play a key role in the brain where they support brain microvascular endothelial cells (BMECs) in forming the tightly regulated blood-brain barrier (BBB).
Michelle A. Trempel +10 more
doaj +1 more source
A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies [PDF]
, 2018 This paper presents the design and fabrication of a multi-layer and multi-chamber microchip system using thiol-ene 'click chemistry' aimed for drug transport studies across tissue barrier models. The fabrication process enables rapid prototyping of multi-
Andresen, Thomas Lars +5 more
core +3 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source