Results 11 to 20 of about 111,766 (263)

Human bone marrow mesenchymal stem cells for retinal vascular injury [PDF]

Acta Ophthalmologica, 2016
AbstractPurposeTo examine the potential of intravitreally implanted human bone marrow‐derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood–retina barrier in mice and rats with oxygen‐induced retinopathy, diabetic retinopathy or retinal ischaemia–reperfusion damage.MethodsThree study groups (oxygen‐induced retinopathy group: 18
Jin‐Da Wang, Ying An, Jing‐Shang Zhang, Xiu‐Hua Wan, Jost B. Jonas, Liang Xu, Wei Zhang   +6 more
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Xeno-free proliferation of human bone marrow mesenchymal stem cells [PDF]

Cytotechnology, 2011
The proliferation of human bone marrow mesenchymal stem cells (MSCs) employing xeno-free materials not containing fetal calf serum (FCS) and porcine trypsin was investigated for the regenerative medicine of cartilage using MSCs. Four sequential subcultivations of MSCs using a medium containing 10% FCS and recombinant trypsin (TrypLESelect™) resulted in
Hiroto, Miwa, Yoshiki, Hashimoto, Keiji, Tensho, Shigeyuki, Wakitani, Mutsumi, Takagi   +4 more
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Bone Marrow Microenvironment-On-Chip for Culture of Functional Hematopoietic Stem Cells

Frontiers in Bioengineering and Biotechnology, 2022
Hematopoiesis takes place in the bone marrow and is supported by a complex cellular and molecular network in the bone marrow microenvironment. Commonly used models of the human bone marrow microenvironment include murine models and two-dimensional and ...
Azmeer Sharipol, Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Celia A. Soto, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch   +8 more
doaj   +1 more source

GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells

Haematologica, 2014
The bone marrow microenvironment comprises multiple cell niches derived from bone marrow mesenchymal stem cells. However, the molecular mechanism of bone marrow mesenchymal stem cell differentiation is poorly understood. The transcription factor GATA2 is
Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Masahiko Kanehira, Shinji Nakajima, Taro Takahashi, Ai Inoue, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae   +12 more
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Extracellular Vesicle Derived From Mesenchymal Stem Cells Have Bidirectional Effects on the Development of Lung Cancer

Frontiers in Oncology, 2022
Mesenchymal stem cell is a kind of pluripotent cells with the ability of self-renewal and multi-directional differentiation, which exist in bone marrow, umbilical cord blood, umbilical cord tissue, placenta tissue, adipose tissue and so on. Extracellular
Jiayu Wang, Jiayu Wang, Jiayu Wang, Yiming Ma, Yiming Ma, Yiming Ma, Yingjiao Long, Yingjiao Long, Yingjiao Long, Yan Chen, Yan Chen, Yan Chen   +11 more
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Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells [PDF]

Journal of Translational Medicine, 2016
Age-associated changes in genomic DNA methylation have been primarily attributed to 5-methylcytosine (5mC). However, the recent discovery of 5-hydroxymethylcytosine (5hmC) suggests that this epigenetic mark might also play a role in the process.Here, we analyzed the genome-wide profile of 5hmc in mesenchymal stem cells (MSCs) obtained from bone-marrow ...
Toraño, Estela G., Bayón, Gustavo F., Real, Álvaro del, Sierra, Marta I., García, María G., Carella, Antonella, Belmonte, Thalia, Urdinguio, Rocío G., Cubillo, Isabel, García Castro, Javier, Delgado Calle, Jesús, Pérez Campo, Flor María, Riancho Moral, José Antonio, Fernández Fraga, Mario, Fernández, Agustín F.   +14 more
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Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Exosomes are membranous lipid vesicles fused with intracellular multicellular bodies and then released into the extracellular environment. They contain various bioactive substances, including proteins, mRNA, miRNAs, lncRNAs, circRNAs, lipids ...
Zhikun Wang, Yangming Wu, Zhonghan Zhao, Chengyi Liu, Lingli Zhang   +4 more
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Characterization of Ionic Currents in Human Mesenchymal Stem Cells from Bone Marrow [PDF]

STEM CELLS, 2005
This study characterized functional ion channels in cultured undifferentiated human mesenchymal stem cells (hMSCs) from bone marrow with whole-cell patch clamp and reverse transcription polymerase chain reaction (RT-PCR) techniques. Three types of outward currents were found in hMSCs, including a noise-like rapidly activating outward current inhibited ...
Sun, H, Li, GR, Lau, CP, Deng, X
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Enhancement of Osteogenesis by Concanavalin a in Human Bone Marrow Mesenchymal Stem Cell Cultures [PDF]

The International Journal of Artificial Organs, 2008
This study investigates concanavalin A (ConA) as a novel factor that may enhance osteogenesis of mesenchymal stem cells (MSCs) in vitro. Various factors, such as cytokine bone morphogenetic protein-2 (BMP-2), have been studied for their possible promotion of MSC osteogenesis in vivo and in vitro. However, the factor that might be safer, more effective,
Sekiya, Kensuke, Nishimura, Masahiro, Suehiro, Fumio, Nishimura, Haruki, Hamada, Taizo, Kato, Yukio   +5 more
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Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern

Genomics Data, 2015
Multipotent mesenchymal stromal cells derived from human placenta (pMSCs), and unrestricted somatic stem cells (USSCs) derived from cord blood share many properties with human bone marrow-derived mesenchymal stromal cells (bmMSCs) and are currently in ...
Nicholas Matigian, Gary Brooke, Faten Zaibak, Tony Rossetti, Katarina Kollar, Rebecca Pelekanos, Celena Heazlewood, Alan Mackay-Sim, Christine A. Wells, Kerry Atkinson   +9 more
doaj   +1 more source