Results 11 to 20 of about 180,484 (312)

Bone Marrow Microenvironment-On-Chip for Culture of Functional Hematopoietic Stem Cells

Frontiers in Bioengineering and Biotechnology, 2022
Hematopoiesis takes place in the bone marrow and is supported by a complex cellular and molecular network in the bone marrow microenvironment. Commonly used models of the human bone marrow microenvironment include murine models and two-dimensional and ...
Azmeer Sharipol, Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Celia A. Soto, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch   +8 more
doaj   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +7 more sources

Human bone marrow mesenchymal stem cells for retinal vascular injury [PDF]

Acta Ophthalmologica, 2016
AbstractPurposeTo examine the potential of intravitreally implanted human bone marrow‐derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood–retina barrier in mice and rats with oxygen‐induced retinopathy, diabetic retinopathy or retinal ischaemia–reperfusion damage.MethodsThree study groups (oxygen‐induced retinopathy group: 18
Jin‐Da Wang, Ying An, Jing‐Shang Zhang, Xiu‐Hua Wan, Jost B. Jonas, Liang Xu, Wei Zhang   +6 more
openaire   +2 more sources

GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells

Haematologica, 2014
The bone marrow microenvironment comprises multiple cell niches derived from bone marrow mesenchymal stem cells. However, the molecular mechanism of bone marrow mesenchymal stem cell differentiation is poorly understood. The transcription factor GATA2 is
Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Masahiko Kanehira, Shinji Nakajima, Taro Takahashi, Ai Inoue, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae   +12 more
doaj   +1 more source

Extracellular Vesicle Derived From Mesenchymal Stem Cells Have Bidirectional Effects on the Development of Lung Cancer

Frontiers in Oncology, 2022
Mesenchymal stem cell is a kind of pluripotent cells with the ability of self-renewal and multi-directional differentiation, which exist in bone marrow, umbilical cord blood, umbilical cord tissue, placenta tissue, adipose tissue and so on. Extracellular
Jiayu Wang, Jiayu Wang, Jiayu Wang, Yiming Ma, Yiming Ma, Yiming Ma, Yingjiao Long, Yingjiao Long, Yingjiao Long, Yan Chen, Yan Chen, Yan Chen   +11 more
doaj   +1 more source

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
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Human amnion‐derived mesenchymal stem cells promote osteogenesis of human bone marrow mesenchymal stem cells against glucolipotoxicity [PDF]

FEBS Open Bio, 2018
Epidemiological evidence suggests that diabetes mellitus (DM) is an important factor in promoting periodontitis. It not only affects the attachment of connective tissue but also causes loss of alveolar bone. Hence, there is an urgent need to find an effective treatment for DM‐induced bone deficiency. This study aimed to investigate the effects of human
Bian, Yifeng, Ma, Xiaojie, Wang, Ruixia, Yuan, Hua, Chen, Ning, Du, Yifei   +5 more
openaire   +2 more sources

Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Exosomes are membranous lipid vesicles fused with intracellular multicellular bodies and then released into the extracellular environment. They contain various bioactive substances, including proteins, mRNA, miRNAs, lncRNAs, circRNAs, lipids ...
Zhikun Wang, Yangming Wu, Zhonghan Zhao, Chengyi Liu, Lingli Zhang   +4 more
doaj   +1 more source

Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow [PDF]

, 2003
Previous studies have provided evidence for the existence of adult human bone marrow stromal stem cells (BMSSCs) or mesenchymal stem cells. Using a combination of cell separation techniques, we have isolated an almost homogeneous population of BMSSCs ...
Graves, S., Gronthos, S., Hay, S., Kortesidis, A., Shi, S., Simmons, P., Zannettino, A.   +6 more
core   +2 more sources

Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo [PDF]

, 2017
Human umbilical cord blood (CB) has attracted much attention as a reservoir for functional hematopoietic stem and progenitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs). Previously, we demonstrated that bone marrow stromal cell (
Biondi, Andrea, Corsi, Alessandro, Donsante, Samantha, Pievani, Alice, Rambaldi, Benedetta, Remoli, Cristina, Riminucci, Mara, Robey, Pamela G., Sacchetti, Benedetto, Scagliotti, Valeria, Serafini, Marta, Vergani, Patrizia   +11 more
core   +2 more sources