Results 261 to 270 of about 180,484 (312)

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source

Homogenous Cell Transplantation Trials in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The transplantation of homogenous cells has emerged as an investigational strategy for Parkinson's disease (PD), offering an alternative to symptomatic treatment. Objective We performed a systematic review and meta‐analysis to assess its clinical efficacy and safety.
Nolan Reinisch, Athena Mancini, Adham Elsherbini, Jason Yuen, Andres Lozano   +4 more
wiley   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, EarlyView.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Biology of Human Primary Bone Marrow Mesenchymal Stromal Stem Cells

, 2017
openaire   +1 more source

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Isolation of mesenchymal stem cells from human placenta: Comparison with human bone marrow mesenchymal stem cells

Cell Biology International, 2006
AbstractThe presence within bone marrow of a population of mesenchymal stem cells (MSCs) able to differentiate into a number of different mesenchymal tissues, including bone and cartilage, was first suggested by Friedenstein nearly 40 years ago. Since then MSCs have been demonstrated in a variety of fetal and adult tissues, including bone marrow, fetal
Zongning, Miao, Jun, Jin, Lei, Chen, Jianzhong, Zhu, Wei, Huang, Jidong, Zhao, Hanguang, Qian, Xueguang, Zhang   +7 more
openaire   +4 more sources

Human Bone Marrow Native Mesenchymal Stem Cells

Regenerative Medicine, 2008
The adult bone marrow (BM) has been generally considered to be composed of hematopoietic tissue and the associated supporting stroma. There is accumulating evidence that a subset of multipotential cells exists within the latter compartment, commonly referred to as mesenchymal stem cells (MSCs).
Charalampos, Pontikoglou, Bruno, Delorme, Pierre, Charbord   +2 more
openaire   +2 more sources

Mesenchymal Stem Cell Content of Human Vertebral Bone Marrow

Transplantation, 2004
Mesenchymal stem cells (MSCs) are capable of down-regulating alloimmune responses and promoting the engraftment of hematopoietic stem cells. MSCs may therefore be suitable for improving donor-specific tolerance induction in solid-organ transplantation.
Norbert, Ahrens, Ariane, Tormin, Margit, Paulus, Daniela, Roosterman, Abdulgabar, Salama, Veit, Krenn, Ulf, Neumann, Stefan, Scheding   +7 more
openaire   +2 more sources

Electrostimulated bone marrow human mesenchymal stem cells produce follistatin

Cytotherapy, 2009
Follistatin (FST) and the related proteins FSTL1 and FSTL3 are crucial modulators of the transforming growth factor (TGF)-beta superfamily and function by neutralizing activins, a group of proteins implicated in many biologic processes, such as cell proliferation and differentiation, immune responses, various endocrine activities, wound repair ...
Jorge A, Genovese, Cristiano, Spadaccio, Hernan Garcia, Rivello, Yoshiya, Toyoda, Amit N, Patel   +4 more
openaire   +2 more sources

Mesenchymal stromal/stem cells markers in the human bone marrow

Cytotherapy, 2013
Mesenchymal stromal/stem cells (MSCs) can be isolated from human bone marrow (BM), expanded ex vivo and identified via numerous surface antigens. Despite the importance of these cells in regenerative therapy programs, it is unclear whether the cell membrane signature defining MSC preparations ex vivo is determined during culture or may reflect an in ...
RASINI, Valeria, DOMINICI, Massimo, Kluba, Torsten, Siegel, Georg, Lusenti, Giulia, Northoff, Hinnak, HORWITZ, EDWIN MARK, Schäfer, Richard   +7 more
openaire   +3 more sources