Results 261 to 270 of about 165,036 (300)

Adult human cardiomyocyte mechanics in osteogenesis imperfecta

American Journal of Physiology-Heart and Circulatory Physiology, 2023
In a rare donation of a heart from an individual with osteogenesis imperfecta (OI), we explored cardiomyocyte (CM) adaptations to low stiffness. This represents the first assessment of cardiomyocyte mechanics in OI. The data reveal the hypercontractility of OI CMs with rapid rundown when exposed to acute stiffness challenges, extending our ...
Benjamin W. Lee, Matthew A. Caporizzo, Christina Y. Chen, Kenneth C. Bedi, Eliot G. Peyster, Benjamin L. Prosser, Kenneth B. Margulies, Alexia Vite   +7 more
openaire   +2 more sources

The human adult cardiomyocyte phenotype

Cardiovascular Research, 2003
Determination of the phenotype of adult human atrial and ventricular myocytes based on gene expression and morphology.Atrial and ventricular cardiomyocytes were obtained from patients undergoing cardiac surgery using a modified isolation procedure. Myocytes were isolated and cultured with or without serum.
Bird, SD, Doevendans, PA, van Rooijen, MA, de la Riviere, AB, Hassink, RJ, Passier, R, Mummery, CL   +6 more
openaire   +3 more sources

Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes

2012
To date, there is no suitable in vitro model to study human adult cardiac cell biology. Here, we describe a method for efficient isolation and expansion of human cardiomyocyte progenitor cells (CMPCs) from cardiac surgical waste or, alternatively, from fetal heart tissue.
Anke M, Smits, Angelique A, van Oorschot, Marie-José, Goumans   +2 more
openaire   +4 more sources

Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype

Journal of Molecular and Cellular Cardiology, 2010
Cardiomyocyte progenitor cells (CMPCs) can be isolated from the human heart and differentiated into cardiomyocytes in vitro. A comprehensive assessment of their electrical phenotype upon differentiation is essential to predict potential future applications of this cell source.
Boer, T.P. de, Veen, T.A.B. van, Jonsson, M.K.B., Kok, B.G.J.M., Metz, C.H.G., Sluijter, J.P.G., Doevendans, P.A., Bakker, J.M.T. de, Goumans, M.J., Heyden, M.A.G. van der   +9 more
openaire   +4 more sources

Cardiomyocytes from Human Embryonic Stem Cells

2006
Terminal heart failure is characterized by a significant loss of cardiac myocytes. Stem cells represent a possibility for replacing these lost myocytes but the question of which stem cells are most ideally suited for cell transplantation therapies is still being addressed.
R, Passier, C, Denning, C, Mummery
openaire   +2 more sources

Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract

Human Cell, 2011
Cell transplantation shows potential for the treatment of cardiac diseases. Embryonic stem cells, cord blood and mesenchymal stem cells have been suggested as sources for transplantation therapy. Because of some technical limitations with the use of stem cells, transdifferentiation of fully differentiated cells is a potentially useful alternative.
Zahra, Vojdani, Sima, Tavakolinejad, Tahereh, Talaei-Khozani, Tahereh, Esmaeilpour, Manuchehr, Rasooli   +4 more
openaire   +2 more sources

Development of Cardiomyocytes from Human ES Cells

2003
Publisher Summary Cell transplantation is emerging as a novel strategy for myocardial regeneration, but it has been hampered by the lack of a source for human cardiomyocytes. Similarly, the lack of a human cardiomyocyte cell line has significantly limited a variety of experimental procedures.
Izhak, Kehat, Michal, Amit, Amira, Gepstein, Irit, Huber, Joseph, Itskovitz-Eldor, Lior, Gepstein   +5 more
openaire   +2 more sources

Cardiomyocyte Differentiation from Human Embryonic Stem Cells

2018
In vitro generated human cardiomyocytes hold the ultimate promise for heart patients for repair of injured or diseased myocardium, but they also provide experimental models for studying normal cardiomyocyte development, for disease modeling and for drug development.
Silvia, Mazzotta, Adam T, Lynch, Stefan, Hoppler   +2 more
openaire   +2 more sources

Cardiomyocytes from embryonic stem cells: towards human therapy

Expert Opinion on Biological Therapy, 2008
Despite improvements in survival with current therapies, it is now clear that major cardiovascular event rates in patients remain high. Cardiac cell replacement therapy by using human embryonic stem cell-derived cardiomyocytes has emerged as a promising future approach to regenerate functional myocardium.
Gábor, Földes, Sian E, Harding, Nadire N, Ali   +2 more
openaire   +2 more sources

Hyperpolarization Induces Differentiation in Human Cardiomyocyte Progenitor Cells

Stem Cell Reviews and Reports, 2010
In the past years, cardiovascular progenitor cells have been isolated from the human heart and characterized. These cells can differentiate into cardiomyocytes, smooth muscle cells and endothelial cells and are therefore of great value for investigation of the mechanisms that drive progenitor cell function and plasticity, drug testing and, potentially,
Vliet, P. van, Boer, T.P. de, Heyden, M.A.G. van der, Tamer, M.K. el, Sluijter, J.P.G., Doevendans, P.A., Goumans, M.J.   +6 more
openaire   +3 more sources