Results 91 to 100 of about 192,493 (241)

Human Epididymis Protein 4 Immunohistochemistry Expression in Benign Ovarian Cysts

, 2018
This study seeks to determine the characteristics of the patient with benign ovarian cysts, the histopathologic distribution of benign ovarian cysts, Human Epididymis Protein 4 (HE4) expression in various benign ovarian cyst tissues and normal ovaries, and to determine an HE4 expression base from histopathologic type.
M Rusda, D Lutan, A Gafur, M F Sahil, T M Ichsan, H L Haryono, Z Z Tala, M I Sari   +7 more
openaire   +1 more source

Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic Fibrosis [PDF]

Chest, 2016
Increased expression of the human epididymis protein 4 (HE4) was previously described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown, however, whether serum HE4 concentrations are elevated in CF.Seventy-seven children with CF from six Hungarian CF centers and 57 adult patients with CF from a Czech center were ...
Béla, Nagy, Béla, Nagy, Libor, Fila, Luka A, Clarke, Ferenc, Gönczy, Olga, Bede, Dóra, Nagy, Rita, Újhelyi, Ágnes, Szabó, Andrea, Anghelyi, Miklós, Major, Zsolt, Bene, Zsolt, Fejes, Péter, Antal-Szalmás, Harjit Pal, Bhattoa, György, Balla, János, Kappelmayer, Margarida D, Amaral, Milan, Macek, István, Balogh   +19 more
openaire   +2 more sources

Biomarker‐Agnostic Detection of Ovarian Cancer from Blood Plasma Using a Machine Learning‐Driven Electronic Nose

Advanced Intelligent Systems, EarlyView.
This study introduces a biomarker‐agnostic diagnostic strategy for ovarian cancer, utilizing a machine learning‐enhanced electronic nose to analyze volatile organic compound signatures from blood plasma. By overcoming the dependence on specific biomarkers, this approach enables accurate detection, staging, and cancer type differentiation, offering a ...
Ivan Shtepliuk, Lingyin Meng, Christer Borgfeldt, Jens Eriksson, Donatella Puglisi   +4 more
wiley   +1 more source

Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility. [PDF]

, 2016
Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated.
Ge, Xin, Guo, Xue-Jiang, He, Jun, Jiang, Bing-Hua, Jiang, Cheng-Fei, Li, Dong-Mei, Li, Wei, Lin, Marie, Liu, Ling-Zhi, Liu, Xue, Qian, Xu, Qian, Ying-Chen, Sha, Jia-Hao, Shen, Hua, Shi, Zhu-Mei, Wang, Lin, Wang, Min, Yin, Yu, Zheng, Bo, Zheng, Ji-Tai   +19 more
core   +2 more sources

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. [PDF]

, 2012
PurposeAs imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody ...
Braun, Jonathan, Brewer, Sarah, Fu, Maoyong, Gordon, Lynn K, Olafsen, Tove, Said, Jonathan, Wadehra, Madhuri, Wu, Anna M   +7 more
core   +3 more sources

Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas [PDF]

Human Pathology, 2013
Upper gastrointestinal neoplasia in the esophagus, stomach, and pancreas is associated with the formation of preneoplastic metaplasias. We have previously reported the up-regulation of human epididymis protein 4 (HE4) in all metaplasias in the stomach of humans and mice.
Ryan L, O'Neal, Ki Taek, Nam, Bonnie J, LaFleur, Brittney, Barlow, Koji, Nozaki, Hyuk-Joon, Lee, Woo Ho, Kim, Han-Kwang, Yang, Chanjuan, Shi, Anirban, Maitra, Elizabeth, Montgomery, M Kay, Washington, Wael, El Rifai, Ronny I, Drapkin, James R, Goldenring   +14 more
openaire   +3 more sources

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Serum HE4 Detects Ovarian Cancer Recurrence Earlier Than CA 125: Indian Study [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Recurrence is a frequent phenomenon of the natural history of epithelial Ovarian Cancer (OC). Early detection of recurrence is important.
Naseem Akhtar, Shiv Rajan, Vijay Kumar, Sonali Sharma, Sumaira Qayoom, Sourabh Mukharjee, Wahid Ali, Arun Chaturvedi   +7 more
doaj   +1 more source

Receptores e função do estrógeno no sistema reprodutor masculino [PDF]

, 2009
A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ERα and ERβ, respectively.
Fernandes, Sheilla Alessandra Ferreira, Gomes, Gisele Renata Oliveira, Lazari, Maria de Fatima Magalhaes, Lucas, Thais Fabiana Gameiro, Porto, Catarina Segreti, Royer, Carine, Siu, Erica Rosanna, Yasuhara, Fabiana   +7 more
core   +2 more sources