Results 121 to 130 of about 192,493 (241)

Role of Human Epididymis Protein 4 (HE4) in Determining Survival of Patients With Endometrial Cancer: A Meta-Analysis

Technology in Cancer Research & Treatment, 2020
Background: Human epididymis protein 4 (HE4) is a novel cancer biomarker. This study evaluates the prognostic role of HE4 in determining the survival of endometrial cancer patients. Methods: Literature search was conducted in electronic databases (Embase,
Ying He MD, Jing Wang MD, Chun-Xing Ma MD, Yan-Hua Kang MD   +3 more
doaj   +1 more source

Characterisation of an alternative splice variant of LKB1

, 2010
The LKB1 protein kinase has previously been implicated in a number of major physiological processes including cell proliferation, polarity and energy metabolism.
Denison, Fiona Clare, Denison, Fiona Clare   +1 more
core   +1 more source

Human Epididymis Protein-4 and Carbohydrate Antigen-125 for Diagnosis of Endometrial Carcinoma

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 )
Background: Endometrial carcinoma (EC) is a common genital tumor that frequently causes abnormal uterine bleeding (AUB). All gynecologists aimed to differentiate between malignant and benign causes of AUB using a noninvasive approach.
Sarah Mahmood Saed, R. Al-Wazzan
semanticscholar   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Comparison of the Serum Level of Cancer Antigen 125 and Human Epididymis Protein 4 in Ovarian Cancer Patients and Healthy Groups in Isfahan City

Advanced Biomedical Research, 2017
Background: Ovarian cancer is the most common fatal malignancy of the gynecology tract. The purpose of this study was to compare serum levels of tumor markers cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in both healthy groups and ...
Mahnaz Bakrani, Kahin Shahani Poor, Valiollah Mehrzad, Nematallah Razmi   +3 more
doaj   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

Intermedin attenuates LPS-induced inflammation in the rat testis [PDF]

, 2013
First reported as a vasoactive peptide in the cardiovascular system, intermedin (IMD), also known as adrenomedullin 2 (ADM2), is a hormone with multiple potent roles, including its antioxidant action on the pulmonary, central nervous, cardiovascular and ...
Huang, C, Li, L, Liu, Y, Ma, P, O, WS, Tang, F, Zhang, JV   +6 more
core   +2 more sources

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models

Andrology, EarlyView.
ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao, Xi Zhang, Lingru Li, Yunzhi Zhang, Shuo Huang, Yulin Zong, Mingrui Li, Fufangyu Zhao, Linghui Zhu, Tianxing Li, Wenlong Sun, Mingyan Shao, Yanfei Zheng   +12 more
wiley   +1 more source

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, EarlyView.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source