Results 191 to 200 of about 192,493 (241)

Expression and biochemical characterization of recombinant human epididymis protein 4

Protein Expression and Purification, 2014
Whey acidic proteins (WAP) belong to a large gene family of antibacterial peptides that perform critical immune system functions. The function of human epididymis protein 4 (HE4), a 124-amino acid long polypeptide that has two whey acidic protein four-disulfide core (WFDC) domains, is not well studied. Here, a fusion gene encoding the HE4 protein fused
Ling, Hua, Yunhui, Liu, Shuai, Zhen, Deyou, Wan, Jiyue, Cao, Xin, Gao   +5 more
openaire   +2 more sources

Verification of the harmonization of human epididymis protein 4 assays

Clinical Chemistry and Laboratory Medicine (CCLM), 2016
Abstract Background: Serum human epididymis protein 4 (HE4) has gained relevance as an ovarian cancer (OC) biomarker and new automated methods have replaced the first released manual EIA by tracing results to it. We verified agreement and bias of automated methods vs.
S. Ferraro, S. Borille, A. Carnevale, E. Frusciante, BASSANI, NICCOLO' PAOLO, M. Panteghini   +5 more
openaire   +2 more sources

Pleural fluid human epididymis secretory protein 4 in differentiating between malignant and benign pleural effusions: a systematic review and meta-analysis

Journal of Thoracic Disease
Background Soluble biomarkers in pleural fluid are a promising diagnostic tool for malignant pleural effusion (MPE) due to their advantages of low cost, short turnaround time, and less invasiveness.
Qian Yang, Ling Hai, Yan Niu, Jian-Xun Wen, Dan-Ni Yang, Su-Na Cha, Hong-Zhe Zhu, Cheng Yan, Li Yan, Ying-Jun Wang, Wenguang Zheng, Zhi-De Hu, Lei Zhang   +12 more
semanticscholar   +1 more source

Serum Human Epididymis Protein 4 as a Prognostic Predictor of New-Onset Heart Failure among Women after Acute Coronary Syndrome: A Single-Center Retrospective Study

The Cardiology, 2023
Introduction: Little is known about the prognostic factors among women with acute coronary syndrome (ACS), partly due to the small number of women included in heart failure (HF) clinical trials.
Qiqi Yan, Liuyang Wu, Jikai Song, Lifang Ye, Qinggang Zhang, Xiaoru Che, Xin Zhang, Lihong Wang   +7 more
semanticscholar   +1 more source

Clinical significance of human epididymis protein 4 (HE4), cancer antigen 125 (CA125), the risk of ovarian malignancy algorithm (ROMA), and Copenhagen index (CPH-I) for the diagnosis of endometrial carcinoma.

Folia Medica
INTRODUCTION Endometrial carcinoma (EC) is the most common gynecological cancer among women, and in more than 90% of cases, the initial manifestation of the disease is postmenopausal bleeding.
Vesselina Koleva, S. Shefket, Snezhana Stoencheva   +2 more
semanticscholar   +1 more source

Human epididymis protein 4 contributes to lower systolic function and poor prognosis in heart failure with reduced ejection fraction

European Heart Journal
Human epididymis protein 4 (HE4) is a novel fibrosis marker exclusively expressed in activated myofibroblast. We previously reported that HE4 serves as a useful biomarker for predicting future adverse cardiovascular events and for assessing left ...
Y. Okuno, S. Hanatani, F. Ogata, M. Yamamoto, Y. Izumiya, K. Tsujita   +5 more
semanticscholar   +1 more source

Reference values of human epididymis protein 4 in the Bulgarian population - assessment of the influence of age, menopause, pregnancy, and renal function.

Folia Medica
INTRODUCTION Human epididymis protein 4 (HE4) is increasingly utilized in diagnosing pelvic masses and monitoring patients with ovarian or endometrial carcinoma.
V. Koleva-Topova, S. Shefket
semanticscholar   +1 more source

Human epididymis protein 4 in endometrial cancer: A meta-analysis

Clinica Chimica Acta, 2018
Serum human epididymis protein 4 (HE4) is a potential marker for endometrial cancer (EC), however, the diagnostic value of HE4 for EC remains controversial. In this study, we performed a meta-analysis to estimate the diagnostic accuracy of serum HE4 for EC.Literature reports of the diagnostic accuracy of serum HE4 for EC were systematically identified ...
Li-Man, Li, Yu-Xuan, Zhu, Yi, Zhong, Tao, Su, Xiao-Ming, Fan, Qian, Xi, Ming-Yong, Li, Jun, Fu, Hong, Tan, Shan, Liu   +9 more
openaire   +2 more sources

Elevated human epididymis protein 4 concentrations in chronic kidney disease

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2012
Background Human epididymis protein 4 (HE4) has recently become an available tumour biomarker for detecting ovarian cancer along with the standard cancer antigen 125 (CA125). However, it is unknown if the levels of HE4 and CA125 may be altered in subjects who have impaired renal function with no ovarian disorders.
Béla, Nagy, Zoárd T, Krasznai, Heidi, Balla, Mária, Csobán, Péter, Antal-Szalmás, Zoltán, Hernádi, János, Kappelmayer   +6 more
openaire   +2 more sources

Efficacy of Cancer Antigen 15-3, Trefoil Factor-3, and Human Epididymis Protein-4 in the Diagnosis of Breast Cancer

Archives of Breast Cancer
Background: Breast cancer (BC) is a significant global health concern, and delayed or frequently inadequate diagnosis has led to fatalities in many women. Consequently, research is needed to evaluate novel biomarkers for BC detection and monitoring.
Huda A. Owaid, A. Jewad
semanticscholar   +1 more source