Results 201 to 210 of about 192,493 (241)

Utility of human epididymis protein 4 in the differential diagnosis of ascites

Clinical Biochemistry, 2023
Human epididymal protein 4 (HE4) may be a useful tool in the differential diagnosis of malignant ascites. The aim of this study was to evaluate the diagnostic utility of HE4 for detecting malignant ascites, taking into account the possible false positives identified with adenosine deaminase (ADA), C-reactive protein (CRP), % polynuclear cells (%PMN ...
Silvia Bérgamo, Jaume Trapé, Laura González-García, Carolina González-Fernández, Carme Vergara, Noelia de-la-Torre, Glòria Trujillo, Dolors Estivill, Marco Antonio Álvarez-González, Laia Bosch, Marta Otero-Viñas, Carmen Bergós, Silvia Catot, Domingo Ruiz-Hidalgo, Sandra Ros, Francesc Sant   +15 more
openaire   +2 more sources

Evaluating the effectiveness of pre-operative diagnosis of ovarian cancer using minimally invasive liquid biopsies by combining serum human epididymis protein 4 and cell-free DNA in patients with an ovarian mass

International Journal of Gynecological Cancer
Objective To assess the feasibility of scalable, objective, and minimally invasive liquid biopsy-derived biomarkers such as cell-free DNA copy number profiles, human epididymis protein 4 (HE4), and cancer antigen 125 (CA125) for pre-operative risk ...
Duco H K Gaillard, P. Lof, E. Sistermans, Tom Mokveld, H. Horlings, C. Mom, Marcel J. T. Reinders, F. Amant, D. van den Broek, L. Wessels, C. Lok   +10 more
semanticscholar   +1 more source

Evaluation of serum human epididymis protein 4 in children with chronic liver diseases

Scandinavian Journal of Clinical and Laboratory Investigation
The aim of this study was to evaluate the role of serum human epididymis protein 4 (HE4) as a non-invasive biomarker for the diagnosis of liver fibrosis in children with chronic liver diseases (CLD).
N. F. Mohamed, Ola Galal Ali Behairy, Manal Sadek El Defrawy, Samar Ahmed Mohamed Elsheraki, R. Khashaba   +4 more
semanticscholar   +1 more source

Human Epididymis Protein 4 (HE4) in Patients with Small-Cell Lung Cancer

Clinical Laboratory, 2016
The aim of the present study was to compare the diagnostic utility of HE4 with NSE, ProGRP, CYFRA 21-1, CEA, and CA 125 and evaluate their prognostic value in patients with small-cell lung cancer (SCLC).HE4, ProGRP, NSE, CYFRA 21-1, CEA, and CA 125 assays were performed in 63 patients with smallcell lung cancer (limited disease (LD) - 41, extensive ...
Ewa, Wojcik, Jadwiga, Tarapacz, Urszula, Rychlik, Zofia, Stasik, Beata, Sas-Korczynska, Piotr, Skotnicki, Jan K, Kulpa   +6 more
openaire   +2 more sources

Human epididymis protein 4: Analysis of national health and nutrition examination survey data.

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2023
Human epididymis protein 4 (HE4) is a tumor marker overexpressed in ovarian cancer and is commonly utilized to aid with diagnosis of an adnexal mass. HE4 levels vary based on pregnancy, age, menopausal status, and tobacco use.The objective of this study was to evaluate population-based data to examine factors that affect HE4 among adult women in the ...
Emily R. Penick, Thomas A. Beltran, Y. S. Choi, Karen L. Wilson   +3 more
semanticscholar   +3 more sources

Human Epididymis Protein 4 Quantification and Interaction Network Analysis in Seminal Plasma

Protein & Peptide Letters, 2019
Background: A well-known tissue marker of ovarian cancer, Human Epididymis protein 4 (HE4) is the member of whey acidic four-disulfide core proteins family. Purified from human seminal plasma and characterized as a cross-class protease inhibitor, HE4 was proposed to shield spermatozoa against proteolytic factors. However, its exact biological function
Krishna, Kant, Anil K, Tomar, Pankaj, Sharma, Bishwajit, Kundu, Sarman, Singh, Savita, Yadav   +5 more
openaire   +2 more sources

Effect of human epididymis protein 4 on hyperoxia-induced bronchial dysplasia in newborn rats

Nucleosides, Nucleotides & Nucleic Acids
Objective The study aimed to elucidate the role and the underlying mechanism of human epididymis protein 4 (HE4) in the pathogenesis of hyperoxia-induced bronchial dysplasia in newborn rats.
Xiaofang Yan, Xing Feng, Yan Gao, Dawei Liu, Lin Bai, Lu Xu   +5 more
semanticscholar   +1 more source

Clinical Evaluation of Human Epididymis Protein 4 as a Biomarker for Epididymitis

Biomarkers in Medicine, 2012
To evaluate HE4 as a potential biomarker for acute epididymitis.HE4 levels in serum were measured in 62 patients with acute epididymitis and 62 age-matched male controls.Both patients with epididymitis and the controls showed median HE4 values of 42 pmol/l (range: 10-560 pmol/l) and 34 pmol/l (range: 2-300 pmol/l), respectively (p = 0.3). Levels of HE4
A, Pilatz, M, Bürger, G, Lüdecke, F, Wagenlehner, W, Weidner   +4 more
openaire   +2 more sources

Human Epididymis Protein 4 (HE4)

Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie, 2018
N. Zulauf, M. H. Bendels, J. Bauer, M. Braun, G. Volante, G. M. Oremek, D. A. Groneberg, D. Brüggmann   +7 more
openaire   +1 more source

A signal-on electrochemical aptasensor for sensitive detection of human epididymis protein 4 based on functionalized metal–organic framework/ketjen black nanocomposite

Journal of Materials Science, 2023
Rongqin Hu, Zhaode Mu, Feng Gong, Min Qing, Yonghua Yuan, Lijuan Bai   +5 more
semanticscholar   +1 more source