Results 81 to 90 of about 192,493 (241)

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]

, 2011
The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
core  

Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). [PDF]

, 2014
Urocortin 1 (UCN) is a 40-amino acid peptide belonging to the corticotrophin-releasing hormone (CRH) family. The biological effects of this peptide are modulated by binding two G-coupled receptors named CRH receptor 1 (CRHR1) and CRH receptor 2 (CRHR2 ...
CIARCIA, ROBERTO, DE LUCA, ADRIANA, LIGUORI, GIOVANNA, MIRABELLA, NICOLA, SQUILLACIOTI, CATERINA, VITTORIA, ALFREDO   +5 more
core   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Determination of reference intervals of serum levels of human epididymis protein 4 (HE4) in Chinese women [PDF]

, 2015
The detailed numbers of subjects from different centers.
Aimin Zhang, Chuanxin Wang, Guixi Zheng, Huijun Li, Huiming Ye, Jing Chen, Liming Cheng, Lin Guo, Peng Zhang, Qishui Ou, Wanli Liu, Wen Liu, Xinyu Wen, Yanchun Huang, Yaping Tian, Yi Xu, Ying Chen, Yishan Huo, Yuelei Xing, Zhongying Zhang, Ziyong Sun   +20 more
core   +2 more sources

Influences of age and sex on the diagnostic accuracy of human epididymis secretory protein 4 for malignant pleural effusion

Scientific Reports
Previous studies have suggested that the presence of human epididymal protein 4 (HE4) in pleural fluid can be used to diagnose malignant pleural effusion (MPE) with moderate accuracy. However, the factors that affect the diagnostic accuracy of HE4 remain
Qian Yang, Yan Niu, Qianghua Zhou, Dan-Ni Yang, Hong-Zhe Zhu, Cheng Yan, Su-Na Cha, Ting-Wang Jiang, Li Yan, Wenguang Zheng, Jian-Xun Wen, Zhi-De Hu   +11 more
semanticscholar   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Beyond the Biomarker: Understanding the Diverse Roles of Human Epididymis Protein 4 in the Pathogenesis of Epithelial Ovarian Cancer

Frontiers in Oncology, 2018
Human epididymis protein 4 (HE4) is an important clinical biomarker used for the detection of epithelial ovarian cancer (EOC). While much is known about the predictive power of HE4 clinically, less has been reported regarding its molecular role in the ...
Nicole E. James, Nicole E. James, Clinton Chichester, Jennifer R. Ribeiro   +3 more
doaj   +1 more source

Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease. [PDF]

, 2018
Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood.
Bernbaum, John G., Hagen, Katie R., Holbrook, Michael R., Huzella, Louis M., Jahrling, Peter B., Johnson, Reed F., Perry, Donna L., Schnell, Matthias J.   +7 more
core   +1 more source

HE4 Transcription- and Splice Variants-Specific Expression in Endometrial Cancer and Correlation with Patient Survival [PDF]

, 2013
We investigated the HE4 variant-specific expression patterns in various normal tissues as well as in normal and malignant endometrial tissues. The relationships between mRNA variants and age, body weight, or survival are analyzed. ICAT-labeled normal and
Attewell, John, Broaddus, Russell, Chen, Haibin, Dowdy, Sean, Drapkin, Ronny, Fu, Alex, Jiang, Shi-Wen, Kalogera, Eleftheria, Li, Jinping, Podratz, Karl   +9 more
core   +2 more sources