Results 21 to 30 of about 122,903 (146)

Purification of infectious human herpesvirus 6A virions and association of host cell proteins [PDF]

Virology Journal, 2007
Background Viruses that are incorporating host cell proteins might trigger autoimmune diseases. It is therefore of interest to identify possible host proteins associated with viruses, especially for enveloped viruses that have been suggested to play a ...
Garoff Henrik, Jacobson Steven, Ahlqvist Jenny, Hammarstedt Maria, Fogdell-Hahn Anna   +4 more
doaj   +3 more sources

gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections. [PDF]

J Virol, 2020
Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and -6B entry into host cells.
Ma J, Jia J, Jiang X, Xu M, Guo J, Tang T, Xu X, Wu Z, Hu B, Yao K, Li L, Tang H.   +11 more
europepmc   +4 more sources

Human Herpesvirus 6A U4 Inhibits Proteasomal Degradation of the Amyloid Precursor Protein. [PDF]

J Virol, 2022
The association of HHV-6A infection with Alzheimer’s disease has attracted increasing attention, although its role and molecular mechanism remain to be established. Our results here indicate that HHV-6A U4 inhibits amyloid precursor protein (APP) degradation.
Tang T, Jia J, Garbarino E, Chen L, Ma J, Li P, Chen X, Wang L, Wen Y, Wang Y, Li L, Yao K, Tang H.   +12 more
europepmc   +3 more sources

Human Herpesvirus 6A U14 Is Important for Virus Maturation. [PDF]

J Virol, 2016
ABSTRACT Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14.
Mori J, Tang H, Kawabata A, Koike M, Mori Y.   +4 more
europepmc   +4 more sources

The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition

Frontiers in Immunology, 2021
The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat, Barbara Seliger, Barbara Seliger, Ofer Mandelboim, Dominik Schmiedel, Dominik Schmiedel   +5 more
doaj   +1 more source

Human herpesvirus 6A and 6B and NK cells [PDF]

Acta Microbiologica et Immunologica Hungarica, 2018
Human herpesvirus 6 (HHV-6) comprises two viral species, HHV-6A and HHV-6B, closely related but differing for pathogenic and biological characteristics. Both viral species are predominantly lymphotropic, infecting T lymphocytes and other lymphoid cells, including natural killer (NK) cells.
Roberta Rizzo, Dario Di Luca
openaire   +4 more sources

Human herpesvirus 6A accelerates AIDS progression in macaques [PDF]

Proceedings of the National Academy of Sciences, 2007
Although HIV is the necessary and sufficient causative agent of AIDS, genetic and environmental factors markedly influence the pace of disease progression. Clinical and experimental evidence suggests that human herpesvirus 6A (HHV-6A), a cytopathic T-lymphotropic DNA virus, fosters the progression to AIDS in synergy with HIV-1.
Lusso P, Crowley RW, Malnati MS, DI SERIO , MARIACLELIA, PONZONI , MAURILIO, Biancotto A, Markham PD, Gallo RC   +7 more
openaire   +4 more sources

Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A [PDF]

Journal of Virology, 1999
ABSTRACT Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can be readily distinguished by comparison of restriction endonuclease profiles and nucleotide sequences. The viruses are similar with respect to genomic and genetic organization, and their genomes cross-hybridize extensively, but ...
G, Dominguez, T R, Dambaugh, F R, Stamey, S, Dewhurst, N, Inoue, P E, Pellett   +5 more
openaire   +2 more sources

Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites

Frontiers in Cellular and Infection Microbiology, 2021
Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani, Cosima Zimmerman, Princess Rodriguez, Ellie Hasenohr, Giulia Aimola, Diana Lea Gerrard, Alyssa Richman, Andrea Dest, Louis Flamand, Benedikt Kaufer, Seth Frietze, Seth Frietze   +11 more
doaj   +1 more source

Human Herpesvirus 6A (HHV-6A) Encephalitis in an Immunocompetent Patient and Its Association With Glioblastoma: A Case Report. [PDF]

Cureus
Human herpesvirus 6 (HHV-6) is a neurotropic virus capable of establishing latency in the central nervous system. While its reactivation is well-documented in immunocompromised individuals, its role in immunocompetent hosts remains unclear. Additionally, growing but inconclusive evidence suggests a potential association between HHV-6 and glioblastoma ...
Aleixo R, Sá R, Ramos I, Valente C.
europepmc   +3 more sources