Results 31 to 40 of about 122,903 (146)

Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration. [PDF]

J Virol, 2017
ABSTRACT Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we
Gravel A, Dubuc I, Wallaschek N, Gilbert-Girard S, Collin V, Hall-Sedlak R, Jerome KR, Mori Y, Carbonneau J, Boivin G, Kaufer BB, Flamand L.   +11 more
europepmc   +4 more sources

Immunomodulation and immunosuppression by human herpesvirus 6A and 6B. [PDF]

Future Virol, 2013
Like other members of the Herpesviridae family, human herpesvirus (HHV)-6A and HHV-6B have developed a wide variety of strategies to modulate or suppress host immune responses and, thereby, facilitate their own spread and persistence in vivo. Long considered two variants of the same virus, HHV-6A and HHV-6B have recently been reclassified as distinct ...
Dagna L, Pritchett JC, Lusso P.
europepmc   +6 more sources

Prevalence of human herpesvirus 6A and 6B during pregnancy [PDF]

Acta Microbiologica et Immunologica Hungarica, 2014
The aim of the present study was to assess the frequency of human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B) infection during pregnancy. 100–100 blood samples were collected from pregnant and non-pregnant women, then nucleic acid was isolated from both plasma and leukocytes fraction.
Mészáros, Beáta, Sápy, Tamás, Gergely, Lajos, Csoma, Eszter   +3 more
openaire   +3 more sources

Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration. [PDF]

PLoS Pathog, 2020
Human herpesviruses 6A and 6B (HHV-6A/B) are unique among human herpesviruses in their ability to integrate their genome into host chromosomes. Viral integration occurs at the ends of chromosomes within the host telomeres. The ends of the HHV-6A/B genomes contain telomeric repeats that facilitate the integration process. Here, we report that productive
Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L.   +6 more
europepmc   +5 more sources

Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. [PDF]

PLoS ONE, 2009
The SalI-L fragment from human herpesvirus 6A (HHV-6A) encodes a protein DR7 that has been reported to produce fibrosarcomas when injected into nude mice, to transform NIH3T3 cells, and to interact with and inhibit the function of p53.
Mariane H Schleimann, Janni M L Møller, Emil Kofod-Olsen, Per Höllsberg   +3 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis. [PDF]

Brain, 2023
Abstract Recent research indicates that multiple sclerosis is preceded by a prodromal phase with elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The effect of environmental risk factors on the extent of axonal injury during this prodrome is unknown. Human herpesvirus 6A (HHV-6A) is associated with an
Grut V, Biström M, Salzer J, Stridh P, Jons D, Gustafsson R, Fogdell-Hahn A, Huang J, Butt J, Lindam A, Alonso-Magdalena L, Bergström T, Kockum I, Waterboer T, Olsson T, Zetterberg H, Blennow K, Andersen O, Nilsson S, Sundström P.   +19 more
europepmc   +5 more sources

Human Herpesviruses 6A and 6B in Reproductive Diseases

Frontiers in Immunology, 2021
Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)—collectively, HHV-6A/B—are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable ...
Anthony L. Komaroff, Roberta Rizzo, Jeffrey L. Ecker   +2 more
doaj   +1 more source

Characterization of the human herpesvirus 6A U23 gene

Virology, 2014
Human herpesvirus 6 (HHV-6), which replicates abundantly in T cells, belongs to the Roseolovirus genus within the betaherpesvirus subfamily. Members of the Roseolovirus genus encode seven unique genes, U20, U21, U23, U24, U24A, U26, and U100. The present study focused on one of these, U23, by analyzing the characteristics of its gene product in HHV-6A ...
Hayashi, Mayuko, Yoshida, Kento, Tang, Huamin, Sadaoka, Tomohiko, Kawabata, Akiko, Jasirwan, Chyntia, Mori, Yasuko   +6 more
openaire   +2 more sources

Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease?

Neural Regeneration Research, 2019
Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease, a common form of dementia that afflicts a large percentage of elderly individuals.
Maria Anele Romeo, Alberto Faggioni, Mara Cirone   +2 more
doaj   +1 more source