Results 41 to 50 of about 122,903 (146)

A human herpesvirus 6A-encoded microRNA: role in viral lytic replication. [PDF]

J Virol, 2015
ABSTRACT Human herpesvirus 6A (HHV-6A), a member of the betaherpesvirus family, is associated with several human diseases. Like all herpesviruses, HHV-6A establishes a lifelong, latent infection in its host. Reactivation of HHV-6A is frequent within the immunosuppressed and immunocompromised populations and results in lytic viral replication ...
Nukui M, Mori Y, Murphy EA.
europepmc   +4 more sources

Recent developments in animal models for human herpesvirus 6A and 6B. [PDF]

Curr Opin Virol, 2014
Progress in the identification of suitable animal models for human herpesvirus (HHV)-6A and HHV-6B infections has been slow. Recently, new models have been established, mainly for HHV-6A, which reproduce some pathological features seen in humans. Neuroinflammatory signs were observed in infected marmosets and CD46-transgenic mice; although viral ...
Horvat B, Berges BK, Lusso P.
europepmc   +6 more sources

The U94 Gene of Human Herpesvirus 6: A Narrative Review of Its Role and Potential Functions

Cells, 2020
Human herpesvirus 6 (HHV-6) is a β-herpesvirus that is highly prevalent in the human population. HHV-6 comprises two recognized species (HHV-6A and HHV-6B).
Elisabetta Caselli, Maria D’Accolti, Francesca Caccuri, Irene Soffritti, Valentina Gentili, Daria Bortolotti, Antonella Rotola, Enzo Cassai, Simona Fiorentini, Alberto Zani, Arnaldo Caruso, Roberta Rizzo, Dario Di Luca   +12 more
doaj   +1 more source

Latency, Integration, and Reactivation of Human Herpesvirus-6

Viruses, 2017
Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into
Shara N. Pantry, Peter G. Medveczky
doaj   +1 more source

Studying the Interactions of U24 from HHV-6 in Order to Further Elucidate Its Potential Role in MS

Viruses, 2022
A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role in multiple sclerosis (MS). Three possible hypotheses have been investigated: (1) U24 from HHV-6A (U24-6A) mimics myelin basic protein (MBP) through analogous ...
Keng-Shuo Pi, Daria Bortolotti, Yurou Sang, Giovanna Schiuma, Silvia Beltrami, Sabrina Rizzo, Alessandra Bortoluzzi, Eleonora Baldi, A. Louise Creagh, Charles A. Haynes, Roberta Rizzo, Suzana K. Straus   +11 more
doaj   +1 more source

Mapping the telomere integrated genome of human herpesvirus 6A and 6B. [PDF]

Virology, 2013
Human herpesvirus 6B (HHV-6B) is the causative agent of roseola infantum. HHV-6A and 6B can reactivate in immunosuppressed individuals and are linked with severe inflammatory response, organ rejection and central nervous system diseases. About 0.85% of the US and UK population carries an integrated HHV-6 genome in all nucleated cells through germline ...
Arbuckle JH, Pantry SN, Medveczky MM, Prichett J, Loomis KS, Ablashi D, Medveczky PG.   +6 more
europepmc   +3 more sources

Impact of Host Telomere Length on HHV-6 Integration

Viruses, 2022
Human herpesvirus 6A and 6B are two closely related viruses that infect almost all humans. In contrast to most herpesviruses, HHV-6A/B can integrate their genomes into the telomeres during the infection process.
Darren J. Wight, Giulia Aimola, Georg Beythien, Louis Flamand, Benedikt B. Kaufer   +4 more
doaj   +1 more source

Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration. [PDF]

J Virol, 2017
ABSTRACTHuman herpesviruses 6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes using a mechanism that remains poorly understood. To achieve a better understanding of the HHV-6A/B integration mechanism, we made use of BRACO-19, a compound that stabilizes G-quadruplex secondary structures and prevents telomere ...
Gilbert-Girard S, Gravel A, Artusi S, Richter SN, Wallaschek N, Kaufer BB, Flamand L.   +6 more
europepmc   +4 more sources

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

Angewandte Chemie, EarlyView.
This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection

Viruses, 2016
Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”.
Joshua Tweedy, Maria Alexandra Spyrou, Max Pearson, Dirk Lassner, Uwe Kuhl, Ursula A. Gompels   +5 more
doaj   +1 more source