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Human pluripotent stem cells in contemporary medicine
Исследования и практика в медицине, 2015 Human pluripotent stem cells (hPSCs) are capable of indefinite proliferation and can be differentiated into any cell type of the human body. Therefore, they are a promising source of cells for treatment of numerous degenerative diseases and injuries ...
S. A. Rodin
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Haematologica, 2010 Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne +13 more
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Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells. [PDF]
PLoS ONE, 2012 Human embryonic germ cells (EGCs) provide a powerful model for identifying molecules involved in the pluripotent state when compared to their progenitors, primordial germ cells (PGCs), and other pluripotent stem cells.
Nikta Pashai +7 more
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Cardiac differentiation of human pluripotent stem cells [PDF]
Journal of Cellular and Molecular Medicine, 2012 AbstractDue to the extremely limited proliferative capacity of adult cardiomyocytes, human embryonic (pluripotent) stem cell derived cardiomyocytes (hESC‐CMs) are currently almost the only reliable source of human heart cells which are suited to large‐scale production.
Jiang, Junjie +5 more
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Scientific Reports, 2017 Human pluripotent stem cells are a potentially powerful cellular resource for application in regenerative medicine. Because such applications require large numbers of human pluripotent stem cell-derived cells, a scalable culture system of human ...
Kazuhiro Ikeda +3 more
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Generation of hypoimmunogenic human pluripotent stem cells [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance To enable cell therapy on a broader scale, the development of universal donor stem cell products that can be administered to multiple patients in need has been proposed, yet a strategy controlling both adaptive and innate immune rejection has not been reported.
Xiao, Han +12 more
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Telomere dynamics in human pluripotent stem cells
Cell Cycle, 2023 Pluripotent stem cells (PSCs) are a promising source of stem cells for regenerative therapies. Stem cell function depends on telomere maintenance mechanisms that provide them with the proliferative capacity and genome stability necessary to multiply and regenerate tissues.
Ma, Buyun +3 more
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Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. [PDF]
PLoS ONE, 2017 Oligodendrocytes myelinate axons and form myelin sheaths in the central nervous system. The development of therapies for demyelinating diseases, including multiple sclerosis and leukodystrophies, is a challenge because the pathogenic mechanisms of ...
Tomoko Yamashita +12 more
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Modeling human infertility with pluripotent stem cells [PDF]
Stem Cell Research, 2017 Human fertility is dependent upon the correct establishment and differentiation of the germline. This is because no other cell type in the body is capable of passing a genome and epigenome from parent to child. Terminally differentiated germline cells in the adult testis and ovary are called gametes. However, the initial specification of germline cells
Chen, Di +4 more
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Stem Cell Research & Therapy, 2019 Background Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity.
Madison McGrath +5 more
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