Results 61 to 70 of about 1,397,705 (353)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
SA Journal of Industrial Psychology, 2016 Orientation: Qualitative research is marked by phenomenal growth and development over the years. Research purpose: This article aims to offer insight into the emerging qualitative methodologies used in the fields of Psychology, Industrial and ...
Sumari O'Neil, Eileen Koekemoer
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Gen Z’s enduring commitment to fitness apps: a comprehensive examination
Cogent Business & ManagementThis study investigates the sustained engagement of Generation Z with fitness apps using the Theory of Consumption Values (TCV) to identify the key determinants influencing this behaviour.
Vinod Sharma +4 more
doaj +1 more source
Emotional Works and Turnover Intention of Sri Lankan Nurses
Kelaniya Journal of Management, 2017 In the quest for the concept of emotional work, it is apparent that comparing to the international context there are much less research done in Sri Lanka.
M.K. Dinithi Padmasiri, A.M.T. Lakmali
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Impact of Employees’ Perceptions of Organizational Downsizing Practices on Their Commitment [PDF]
Kelaniya Journal of ManagementSri Lanka is presently facing with its most severe financial crisis in decades, with the building and construction sector being significantly affected. This study aims to investigate whether employees’ perceptions of organizational downsizing practices ...
M. D. K. Erandika, V. R. Ranasinghe
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Psychological and Demographic Drivers of Embedded EV Insurance Adoption in Taiwan, China
World Electric Vehicle JournalThe rapid diffusion of electric vehicles (EVs) is reshaping mobility markets and creating new opportunities for embedded financial services. This study examines consumer acceptance of embedded EV insurance, which refers to coverage bundled directly at ...
Jian Liu, Haigang Zhuang, Chiang-Ku Fan
doaj +1 more source
Procedural Justice in Selection from the Lens of Psychological Contract Theory
Organizacija, 2020 Background and purpose: In recruitment and selection, job applicants do not only base their justice judgment on the actual experience but also compare what happens and what they expect.
Huy Phuong Tran +3 more
doaj +1 more source