Results 41 to 50 of about 128,726 (309)

Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival

Communications Biology, 2022
Melatonin induces Parkin 1 dependent mitophagy in human umbilical vein endothelial cells through the AMPK/TFEB pathway, alleviating oxidative stress and apoptosis, which also enables skin flap survival in vivo.
Zhengtai Chen, Hongqiang Wu, Jianxin Yang, Baolong Li, Jian Ding, Sheng Cheng, Nageeb Bsoul, Chenxi Zhang, jiaorong li, Haixiao Liu, Damu Lin, Weiyang Gao   +11 more
doaj   +1 more source

Implications of Endothelial Cell-Mediated Dysfunctions in Vasomotor Tone Regulation

Biologics, 2021
Cardiovascular diseases (CVD) constitute the major cause of death worldwide and show a higher prevalence in the adult population. The human umbilical cord consistsof two arteries and one vein, both composed of three tunics.
Carolina Mangana, Margarida Lorigo, Elisa Cairrao   +2 more
doaj   +1 more source

Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine. [PDF]

, 2003
Background— Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial cells. This effect has been attributed to increased expression and enzymatic activity of both the constitutive and inducible ...
Cartwright, JE, Holden, DP, Nussey, SS, Whitley, GS   +3 more
core   +1 more source

Sphingosylphosphorylcholine Stimulates CCL2 Production from Human Umbilical Vein Endothelial Cells [PDF]

The Journal of Immunology, 2011
Abstract Sphingosylphosphorylcholine (SPC) is a component of high-density lipoprotein particles. We investigated the functional role of SPC in HUVECs. SPC stimulation induced production of the CCL2 chemokine in a PTX-sensitive G-protein–dependent manner.
Ha Young, Lee, Sun Young, Lee, Sang Doo, Kim, Jae Woong, Shim, Hak Jung, Kim, Young Su, Jung, Jae Young, Kwon, Suk-Hwan, Baek, Junho, Chung, Yoe-Sik, Bae   +9 more
openaire   +2 more sources

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor

International Journal of Vascular Medicine, 2013
Angiogenesis is a crucial step in the growth of cancer and its metastasis. It is regulated by several endogenous factors which may stimulate or inhibit the new blood vessel growth.
A. P. Athira, A. Helen, K. Saja, P. Reddanna, P. R. Sudhakaran   +4 more
doaj   +1 more source

Phospholipid molecular species in human umbilical artery and vein endothelial cells.

Journal of Lipid Research, 1990
Molecular species of several phospholipid classes and subclasses were quantitatively determined in human umbilical artery and vein endothelial cells.
H Takamura, H Kasai, H Arita, M Kito
doaj   +1 more source

Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells [PDF]

International Journal of Molecular Sciences, 2019
The serine protease high-temperature-required protein A2 (HtrA2) has been identified as a key intracellular molecule promoting apoptosis in cells during ischemia reperfusion (IR) injury. IR injury in ST-segment elevation myocardial infarction (STEMI) contributes to overall myocardial damage. HtrA2 has further been shown to be significantly increased in
Kaur, Gurpinder, Stallmann, Daniela, Schanze, Nancy, Laumann, Rosemarie, Heger, Lukas Andreas, Steinfurt, Johannes, Stachon, Peter, Peter, Karlheinz, Bode, Christoph, Moser, Martin, Ahrens, Ingo, Dürschmied, Daniel Frank, Hortmann, Marcus   +12 more
openaire   +3 more sources

The establishment of primary and transformed human vascular endothelial cell models [PDF]

Jichu yixue yu linchuang
Objective To establish primary and simian virus 40 (SV40) T antigen transformed human vascular endothelial cell models, and provide available resources for endothelial research.
FENG Hailiang, KONG Linghua, DAI Jiayin, YANG Zhenli, BIAN Xiaocui, LIU Yuqin
doaj   +1 more source

Exosomes derived from human umbilical cord mesenchymal stem cells inhibit vein graft intimal hyperplasia and accelerate reendothelialization by enhancing endothelial function

Stem Cell Research & Therapy, 2020
Background In our previous research, we found that mesenchymal stem cell (MSC) transplantation therapy can inhibit intimal hyperplasia and enhance endothelial function in arterialized vein grafts in rats.
Qingxi Qu, Yingxin Pang, Chunmei Zhang, Linghong Liu, Yanwen Bi   +4 more
doaj   +1 more source