Results 91 to 100 of about 5,553,804 (280)
Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins [PDF]
, 2012 This chapter focuses on the aggregation of glutamine containing peptides and proteins with an emphasis on huntingtin protein, whose aggregation leads to the development of Huntington's disease. The kinetics that leads to the formation of amyloids, the structure of aggregates of various types and the morphological mechanical properties of amyloid ...
Alexey V. Krasnoslobodtsev +2 more
openaire +3 more sources
Probing How Anti‐huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid‐State NMR
Chemistry – A European Journal, EarlyView.Antibodies are widely used to recognize, detect, and target aggregated and misfolded amyloid‐forming proteins, including those associated with HD. Studying such interactions on a structural level is a challenge. Parlato and colleagues report on their use of solid‐state NMR and electron microscopy to probe how such antibodies bind to the fuzzy coat of ...
Raffaella Parlato +3 more
wiley +1 more source
Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. [PDF]
, 2018 Huntington disease (HD) is a late-onset genetic neurodegenerative disorder caused by expansion of cytosine-adenine-guanine (CAG) trinucleotide in the exon 1 of the gene encoding the polyglutamine (polyQ).
Digman, Michelle A +3 more
core +2 more sources
Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity
Molecular Therapy: Nucleic Acids, 2018 The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington’s disease (HD), a debilitating neurodegenerative disorder.
Baehyun Shin +12 more
doaj +1 more source
Exploration, EarlyView.Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang +4 more
wiley +1 more source
Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease [PDF]
, 2009 Huntington's disease (HD) is an autosomal dominant neurodegenerative disease resulting from the expansion of a glutamine repeat in the huntingtin (Htt) protein.
Ko, Jan +2 more
core +2 more sources
EMBO Molecular Medicine, 2013 In Huntington disease (HD), polyglutamine expansion in the huntingtin protein causes specific neuronal death. The consequences of the presence of mutant huntingtin in other tissues are less well understood.
Cristovão Moreira Sousa +8 more
doaj +1 more source
Journal of Biological Chemistry, 2012 Background: Huntingtin is a large nuclear protein with no previously identified nuclear localization signal. Results: Huntingtin has a PY-NLS that is recognized by karyopherin β1 and β2.
Carly R. Desmond +3 more
semanticscholar +1 more source
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
HIP1 (huntingtin interactin protein 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HIP1 (huntingtin interactin protein 1), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources