Results 101 to 110 of about 19,301 (228)
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés +13 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Clinical Genetics, Volume 109, Issue 2, Page 352-355, February 2026.We present the first published case of HYPK‐related neurodevelopmental disorder in a male proband with atypical facies, developmental delay, and autism spectrum disorder– like features. HYPK is a part of the NatA complex, like NAA10 and NAA15, with dysfunction leading to similar but milder features to those of Ogden Syndrome.
Rahi Patel +10 more
wiley +1 more source
Protein tandem repeats that produce frameshifts can generate new structural states and functions
The FEBS Journal, Volume 293, Issue 3, Page 842-858, February 2026.We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli +8 more
wiley +1 more source
PLoS ONE, 2011 Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a trinucleotide (CAG)(n) repeat expansion in the coding sequence of the huntingtin gene, and an expanded polyglutamine (>37Q) tract in the protein. This results in misfolding and accumulation of huntingtin protein (htt), formation of neuronal intranuclear and ...
David C Butler, Anne Messer
openaire +4 more sources
Salivary Huntingtin protein is uniquely associated with clinical features of Huntington's disease. [PDF]
Sci Rep, 2023 Parkin GM +7 more
europepmc +1 more source
Apoptotic Regulation by the Huntingtin Protein
, 2001 Title page and contents Chapter I - Introduction 1 A Matter of Death 1 1.1 Necrosis 1 1.1.1 Morphological Features of Necrosis 2 1.2 Apoptosis 2 1.2.1 Morphological Features of Apoptosis 3 1.3 Apoptosis and Necrosis: A Continuum? 4 2 The Molecular Components of Apoptosis 2.1 Death Receptors 5 2.2 Bcl-2 Family 6 2.3 Apaf-1 Family 7 2.4 Caspases 7 2.5 ...
openaire +1 more source
Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates. [PDF]
Mol Biol Cell, 2022 Bae D +5 more
europepmc +1 more source
Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers. [PDF]
Front Mol Biosci, 2023 Khaled M, Strodel B, Sayyed-Ahmad A.
europepmc +1 more source