Results 121 to 130 of about 5,553,804 (280)

The mRNA expression of SETD2 in human breast cancer: Correlation with clinico-athological parameters [PDF]

, 2009
BACKGROUND: SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes.
AP Cuthbert, AP Wolffe, BD Strahl, BM Turner, C Prives, DS Goodsell, JW Edmunds, K Mokbel, LA Passani, M Li, P Xie, PW Faber, RF Newbold, S Rega, T Roberts, VA Spencer, W Al Sarakbi, W Sasi, WG Jiang, WG Jiang, WG Jiang, WG Jiang, XJ Sun   +22 more
core   +4 more sources

Sub-diffraction imaging of huntingtin protein aggregates by fluorescence blink-microscopy and atomic force microscopy.

ChemPhysChem, 2011
Neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases are all associated with protein misfolding, aggregation, and the accumulation of insoluble amyloid aggregates in neurons.[1] Huntington’s disease is caused by ...
Whitney C. Duim, B. Chen, J. Frydman, W. Moerner   +3 more
semanticscholar   +1 more source

Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms ...
Barbara Baldo, Rana Soylu, Asa Petersén
doaj   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Biomarkers for Huntington's disease: an update [PDF]

, 2012
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Scahill, RI, Tabrizi, SJ, Wild, EJ
core   +1 more source

In Vitro and in Vivo Aggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production*

Journal of Biological Chemistry, 2011
Background: Neurodegenerative diseases are associated with intracellular protein aggregation and free radical damage. Results: Protein aggregation of polyglutamine-containing proteins directly causes free radical production in vitro and within cells ...
S. Hands, M. Sajjad, Michael J Newton, A. Wyttenbach   +3 more
semanticscholar   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, Volume 45, Issue 5, Page 1452-1465, September 2025.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]

, 2018
Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco, De Virgilio, A, Fusconi, M, GRECO, Antonio, Inghilleri, M, Ralli, M   +5 more
core   +1 more source

Targeting Huntingtin Expression in Patients with Huntington's Disease.

New England Journal of Medicine, 2019
BACKGROUND Huntington's disease is an autosomal-dominant neurodegenerative disease caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin protein.
S. Tabrizi, B. Leavitt, G. Landwehrmeyer, E. Wild, C. Saft, Roger A. Barker, Nick F. Blair, D. Craufurd, J. Priller, H. Rickards, A. Rosser, H. Kordasiewicz, C. Czech, E. Swayze, D. Norris, Tiffany L. Baumann, I. Gerlach, S. Schobel, E. Paz, Anne V Smith, C. Bennett, Roger M. Lane   +21 more
semanticscholar   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source