Results 121 to 130 of about 33,531 (157)

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. [PDF]

Elife, 2017
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.   +20 more
europepmc   +1 more source

Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington's Disease. [PDF]

Neurosci Bull, 2019
Yang W, Xie J, Qiang Q, Li L, Lin X, Ren Y, Ren W, Liu Q, Zhou G, Wei W, Saiyin H, Ma L.   +11 more
europepmc   +1 more source

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay. [PDF]

eNeuro, 2018
Baldo B, Sajjad MU, Cheong RY, Bigarreau J, Vijayvargia R, McLean C, Perrier AL, Seong IS, Halliday G, Petersén Å, Kirik D.   +10 more
europepmc   +1 more source

Juvenile Huntington's Disease Skin Fibroblasts Respond with Elevated Parkin Level and Increased Proteasome Activity as a Potential Mechanism to Counterbalance the Pathological Consequences of Mutant Huntingtin Protein. [PDF]

Int J Mol Sci, 2019
Aladdin A, Király R, Boto P, Regdon Z, Tar K.   +4 more
europepmc   +1 more source

Quantification of huntingtin protein species in Huntington's disease patient leukocytes using optimised electrochemiluminescence immunoassays. [PDF]

PLoS One, 2017
Hensman Moss DJ, Robertson N, Farmer R, Scahill RI, Haider S, Tessari MA, Flynn G, Fischer DF, Wild EJ, Macdonald D, Tabrizi SJ.   +10 more
europepmc   +1 more source

The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications. [PDF]

Front Neurosci, 2017
Masnata M, Cicchetti F.
europepmc   +1 more source

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. [PDF]

J Huntingtons Dis, 2018
Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS.   +14 more
europepmc   +1 more source

Human-to-mouse prion-like propagation of mutant huntingtin protein. [PDF]

Acta Neuropathol, 2016
Jeon I, Cicchetti F, Cisbani G, Lee S, Li E, Bae J, Lee N, Li L, Im W, Kim M, Kim HS, Oh SH, Kim TA, Ko JJ, Aubé B, Oueslati A, Kim YJ, Song J.   +17 more
europepmc   +1 more source

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates. [PDF]

PLoS One, 2017
Schut MH, Patassini S, Kim EH, Bullock J, Waldvogel HJ, Faull RLM, Pepers BA, den Dunnen JT, van Ommen GB, van Roon-Mom WMC.   +9 more
europepmc   +1 more source

Downregulation of huntingtin-associated protein 1 predicts poor prognosis in gastric cancer. [PDF]

World J Clin Oncol
Wang XY, Yang FH, Yuan ZY, Wang ZJ, Zhang HF, Xu ZH.   +5 more
europepmc   +1 more source