Results 131 to 140 of about 5,553,804 (280)

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin [PDF]

, 2009
Background: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage
Brundin, Patrick, Khoshnan, Ali, Ko, Jan, Patterson, Paul H., Tescu, Simona   +4 more
core   +3 more sources

Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.

PLoS ONE, 2015
Huntington's disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular changes and ultimately results in neurodegeneration of striatal neurons. Although many theories have
Sayani Dasgupta, Michael A Fishman, Hana Mahallati, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Lloyd D Fricker   +6 more
doaj   +1 more source

The Beneficial Effects of Berberine on Brain Functions in Age‐Related Neurological Disorders: From Molecular Signaling to Treatment

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The positive influence of berberine on the nervous system can be attributed to its diverse effects on multiple targets. The effects of berberine include its antioxidant, anti‐apoptotic, anti‐necroptotic, and anti‐inflammatory properties, as well as its ability to induce autophagy.
Xiaolan Wang, Ruiliang Hou, Zhihao Chen, Xiaoyang Wang, Melika Malek, Haoyu Wang   +5 more
wiley   +1 more source

Along‐Tract Diffusion Alterations in the Dentato‐Rubro‐Thalamic Tract Correlate With Motor and Cognitive Decline in Huntington's Disease

Human Brain Mapping, Volume 46, Issue 11, 01 August 2025.
Our study analyzed longitudinal diffusion MRI data from healthy and Huntington's disease (HD) individuals to investigate the dentato‐rubro‐thalamic tract (DRTT) in HD. Microstructural disruptions along the DRTT were linked to motor and cognitive impairments, suggesting cerebellar involvement in disease progression and highlighting DRTT alterations as ...
Zexi Wang, Alexia Solomon, Janine M. Lupo, Jingwen Yao   +3 more
wiley   +1 more source

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease [PDF]

, 2017
Huntington’s disease (HD) is a polyglutamine (polyQ) disease caused by aberrant expansion of the polyQ tract in Huntingtin (HTT). While motor impairment mediated by polyQ-expanded HTT has been intensively studied, molecular mechanisms for nonmotor ...
Akira Sawa, Amy Gathercole, Cramer, Duman, Eiki Takimoto, Elaine Huston, Fatemi, Hamburg, Harrison, Hideyuki Sasaki, Houslay, Huston, Kandel, Kazuhiro Ishii, Kelvin Kai-Wan Hui, Koko Ishizuka, MacKenzie, Mao, Masaru Kurosawa, Miles D. Houslay, Motomasa Tanaka, Nobuyuki Nukina, Nollet, Noriko Takashima, Ryo Endo, Sawamura, Seshadri, Seshadri, Sun-Hong Kim, Tyedmers, Yoko Nekooki-Machida, Yusuke Komi   +31 more
core   +2 more sources

Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics

Neurobiology of Disease, 2008
Huntington's disease is caused by polyglutamine expansion in the huntingtin protein. Huntingtin directly interacts with profilin, a major actin monomer sequestering protein and a key integrator of signals leading to actin polymerization.
Barrington G. Burnett, Jaime Andrews, Srikanth Ranganathan, Kenneth H. Fischbeck, Nicholas A. Di Prospero   +4 more
doaj  

Detection of alpha-rod protein repeats using a neural network and application to huntingtin.

PLoS Computational Biology, 2009
A growing number of solved protein structures display an elongated structural domain, denoted here as alpha-rod, composed of stacked pairs of anti-parallel alpha-helices.
Gareth A Palidwor, Sergey Shcherbinin, Matthew R Huska, Tamas Rasko, Ulrich Stelzl, Anup Arumughan, Raphaele Foulle, Pablo Porras, Luis Sanchez-Pulido, Erich E Wanker, Miguel A Andrade-Navarro   +10 more
doaj   +1 more source

Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.
Curcumin regulates several signaling pathways linked to neuroprotection, such as those that reduce oxidative stress, prevent Aβ formation, and decrease neuroinflammation. ABSTRACT Progressive neuronal loss and dysfunction characterize neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, and Huntington's diseases, spinal cord injury, and ...
Md. Rezaul Islam, Abdur Rauf, Sumiya Akter, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Md. Tazul Islam, Hassan A. Hemeg, Waleed Al Abdulmonem, Abdullah S. M. Aljohani, Marcello Iriti   +11 more
wiley   +1 more source

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus

Frontiers in Molecular Biosciences, 2019
Huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. The polyglutamine tract is
Havva Yalinca, Charlotte Julie Caroline Gehin, Vladimiras Oleinikovas, Hilal A. Lashuel, Francesco Luigi Gervasio, Francesco Luigi Gervasio, Annalisa Pastore   +6 more
doaj   +1 more source