Data-driven Huntington’s disease progression modelling and estimation of societal cost in the UK
Royal Society Open ScienceWe develop a Huntington’s disease (HD) progression model and integrate this with a novel economic model, accounting for the major factors of the HD’s societal cost.
Andrew Pollard +5 more
doaj +1 more source
Longitudinal study of informed consent in innovative therapy research: experience and provisional recommendations from a multicenter trial of intracerebral grafting. [PDF]
PLoS ONE, 2015 There is an urgent need to assess and improve the consent process in clinical trials of innovative therapies for neurodegenerative disorders.We performed a longitudinal study of the consent of Huntington's disease patients during the Multicenter Fetal ...
Laurent Cleret de Langavant +12 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang +15 more
wiley +1 more source
Silencing Huntington's chorea: Is RNA Interference a Potential Cure? [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 In 1872, George Huntington described Huntington's disease as characterized by motor, cognitive and psychiatric impairments. Huntington's disease is a dominant and autosomal mutation on chromosome 4 featuring the insertion of numerous CAG repeats.
Gerlinde A. Metz +3 more
doaj
Revista Finlay, 2023 Foundation: biomarkers of oxidative stress in Huntington's disease could predict the course of the disease and evaluate new treatments, but their nonspecific nature seems to prevent the identification of any useful marker.
Marisol Peña Sánchez +5 more
doaj
nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge. [PDF]
, 2013 Huntington's disease (HD) is a neurodegenerative condition characterized by severe neuronal loss in the cortex and striatum that leads to motor and behavioral deficits.
Canzoniero, Lorella MT +5 more
core +2 more sources
P2X7 Receptor Agonist 2′(3′)-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington’s Disease [PDF]
, 2021 Alberto Martire +4 more
openalex +1 more source
Advanced Science, EarlyView.Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao +4 more
wiley +1 more source
The right not to know: the case of psychiatric disorders [PDF]
, 2011 This paper will consider the right not to know in the context of psychiatric disorders. It will outline the arguments for and against acquiring knowledge about the results of genetic testing for conditions such as breast cancer and Huntington's disease ...
Bortolotti, L., Widdows, H.
core +2 more sources