Results 61 to 70 of about 52,129 (204)

Visual control improves the accuracy of hand positioning in Huntington’s disease

Aktualności Neurologiczne, 2017
Background: The study aimed at demonstrating dependence of visual feedback during hand and finger positioning task performance among Huntington’s disease patients in comparison to patients with Parkinson’s disease and cervical dystonia.
Emilia J. Sitek, Witold Sołtan, Agnieszka Konkel, Dariusz Wieczorek, Michał Schinwelski, Piotr Robowski, Jarosław Sławek   +6 more
doaj   +1 more source

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity [PDF]

, 2008
Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected.
Bugg, Charles W., Dunn, Denise E., Khoshnan, Ali, Lo, Donald C., Patterson, Paul H., Southwell, Amber L.   +5 more
core   +2 more sources

Additional file 1: of Manifestation of Huntingtonâ s disease pathology in human induced pluripotent stem cell-derived neurons

, 2016
Figure S1. PSC lines characterization. Figure S2. HD and WT PSC derived neurons analysis. Figure S3. Nuclear indentations in HD PSC derived neurons. Figure S4. Classification of up-regulated genes in HD neurons compared to WT neurons with GOrilla tool by molecular function. Figure S5.
Nekrasov, Evgeny, Vigont, Vladimir, Klyushnikov, Sergey, Lebedeva, Olga, Vassina, Ekaterina, Bogomazova, Alexandra, Chestkov, Ilya, Semashko, Tatiana, Kiseleva, Elena, Suldina, Lyubov, Bobrovsky, Pavel, Zimina, Olga, Ryazantseva, Maria, Skopin, Anton, Illarioshkin, Sergey, Kaznacheyeva, Elena, Lagarkova, Maria, Kiselev, Sergey   +17 more
openaire   +1 more source

Additional file 1: of Unmet needs for healthcare and social support services in patients with Huntingtonâ s disease: a cross-sectional population-based study

, 2015
The Needs and Provision Complexity Scale. (PDF 102 kb)
Walsem, Marleen Van, Howe, Emilie, Iversen, Kristin, Frich, Jan, Andelic, Nada   +4 more
openaire   +1 more source

PromOTing Quality of Life for Individuals with Huntington’s Disease [PDF]

, 2015
Objectives of Presentation: Describe the symptoms of Huntington’s disease and their impact on functional performance. Recognize the role of occupational therapy in improving quality of life for individuals with Huntington’s disease.
Gentile, OTS, Lyndsay, Koch, OTS, Mallory, McCabe, OTS, Elyse, Royal, OTS, Jessica, Sadofsky, OTS, Sarah   +4 more
core   +1 more source

Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease. [PDF]

, 2011
There is much interest in the use of mesenchymal stem cells/marrow stromal cells (MSC) to treat neurodegenerative disorders, in particular those that are fatal and difficult to treat, such as Huntington's disease.
Annett, Geralyn, Bauer, Gerhard, Cary, Whitney, Dunbar, Gary, Kambal, Amal, Kim, Hyun Sook, McGee, Jeannine, Mitchell, Gaela-Marie, Nolta, Jan A, Olson, Scott D, Pollock, Kari, Stewart, Heather, Tempkin, Jeremy, Tempkin, Teresa, Wheelock, Vicki   +14 more
core   +3 more sources

Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset [PDF]

Proceedings of the National Academy of Sciences, 2004
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a triplet (CAG) expansion mutation. The length of the triplet repeat is the most important factor in determining age of onset of HD, although substantial variability remains after controlling for repeat length.
Young, AB, Cherny, SS, Landwehrmeyeri, B, Higgins Jr, DS, Hogarth, P, Peery, S, Krch, D, Brickman, A, Paulsen, J, O'Brien, CJ, Dure, L, Young, A, Thompson, LM, Fischbeck, K, Alvir, J, Acosta, L, AcevedoCruz, A, Arnheim, N, Feigin, A, Rey, GJ, Shoulson, I, Marshall, F, Ramos, JS, Bickham, J, RamosArroyo, MA, MartinezJaurrieta, MD, Snodgrass, SR, Negrette, A, Stillings, T, Bonilla, E, Mieja De Young, M, Housman, DE, Andresen, JM, MacDonald, M, Hollingsworth, Z, Hersch, S, Rosas, D, Irizarry, M, Cha, JH, Gusella, J, Penney, JB, Conneally, PM, Hodes, ME, Wiktorski, S, Dlouhy, SR, Gray, J, Cardon, LR, Brocklebank, D, Gayán, J, Roberts, SA, Penchaszadeh, G, Marder, K, Shackell, E, Moskowitz, C, Gomez, F, Porter, J, Lorimer, J, Wexler, NS   +57 more
openaire   +5 more sources

Huntington\u27s Disease--A Review [PDF]

, 2016
Huntington’s disease is degenerative and effects both cognitive and motor functioning, beginning in the 20s and continuing a decline for about two decades until death.
Dunn, Christen
core   +1 more source

Additional file 1: of The dynamics of early-state transcriptional changes and aggregate formation in a Huntingtonâ s disease cell model

, 2017
Additional probes used on the microarray. Probes added to the default Nimblegen library to interrogate additional rat genes (A) or as expression controls for eGFP-Htt levels (B). (PDF 34Â kb)
Hagen, Martijn Van, Piebes, Diewertje, Leeuw, Wim De, Vuist, Ilona, Roon-Mom, Willeke Van, Moerland, Perry, Pernette Verschure   +6 more
openaire   +1 more source

Metabolic and transcriptomic analysis of Huntington's disease model reveal changes in intracellular glucose levels and related genes. [PDF]

, 2017
Huntington's Disease (HD) is a neurodegenerative disorder caused by an expansion in a CAG-tri-nucleotide repeat that introduces a poly-glutamine stretch into the huntingtin protein (mHTT).
Chaves, Gepoliano, Costa, Yvonne Da, Hadiprodjo, Hana, Pourmand, Nader, Rao, Namrata V, Tokuno, Zachary, Özel, Rıfat Emrah   +6 more
core   +2 more sources