Extended release huperzine for the treatment of idiopathic epilepsy in dogs – a Case Report [PDF]
Frontiers in Veterinary ScienceHuperzine is a naturally occurring alkaloid derived from the Chinese clubmoss Huperzia serrata. It is a potent acetylcholinesterase inhibitor, among other properties, and has demonstrated protection against induced seizures in a mouse model of Dravet’s ...
Kylie L. Grant, Sam N. Long
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A perspective on the mechanisms of herbal medicine for cognitive impairment [PDF]
Frontiers in NeurologyCognitive impairment (CI) represents a critical public health burden exacerbated by aging populations and inadequate therapeutic options. Conventional treatments usually target single molecules, which limits their effectiveness in addressing the complex ...
Si-yuan Zheng +2 more
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Guangxi ZhiwuAuxin response factor (ARF) is a transcription factor family that mediates auxin signaling and regulates various biological processes. To investigate the ARF gene family members and their roles in response to high temperature and drought stress, the ...
LI Haibo +7 more
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Co-cultivation Serratia marcescens with Trichoderma harzianum for improving production of Huperzine A [PDF]
Applied Microbiology and BiotechnologyPlant-derived (−)-Huperzine A (HupA), the bioactive enantiomer of the acetylcholinesterase inhibitor used for Alzheimer’s disease (AD) therapy, is limited by the scarcity of Huperzia serrata (HS), while chemically synthesized (+)-HupA is clinically ...
Han Wen-Xia +9 more
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Complete chloroplast genome of a valuable medicinal plant, Huperzia serrata (Lycopodiaceae), and comparison with its congener. [PDF]
Appl Plant Sci, 2016 Premise of the study: Here we report the complete chloroplast genome of the important medicinal species Huperzia serrata (Lycopodiaceae) and compare it to the chloroplast genome of the congeneric species H. lucidula.
Guo ZY, Zhang HR, Shrestha N, Zhang XC.
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Neuroprotective Effects of Huperzine B and <i>Huperzia carinata</i> Extract Against MPP<sup>+</sup>-Induced Oxidative Stress in SH-SY5Y Cells. [PDF]
Adv Pharmacol Pharm SciParkinson’s disease (PD) is a neurodegenerative disorder associated with dopaminergic neuronal loss, mitochondrial dysfunction, and redox imbalance. Huperzine B (HupB), an alkaloid derived from Huperzia species, has demonstrated antioxidant and acetylcholinesterase‐inhibitory activity; however, its effects in toxin‐induced cellular models of ...
Viwatpinyo K +6 more
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Geographical variation in morphological leaf traits of Huperzia serrata (lycopodiaceae) from Vietnam [PDF]
, 2019 Morphological leaf traits can be used to assess adaptive responses of plants to environmental conditions. To assess how the representation of Huperzia serrata leaf traits, such as leaf length (LL), leaf width (LW) and leaf area (LA) response to changes ...
Nguyen Thi Ai Minh +7 more
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Lecanicillium aphanocladii: a biocontrol agent against insect pests and phytopathogens. [PDF]
Pest Manag SciRecent research findings on the biocontrol potential of Lecanicillium aphanocladii fungus against insect‐pests and plant diseases were highlighted. This review indicates that several L. aphanocladii strains show great potential to be developed as multipurpose biocontrol agents active against several insect‐pests, plant diseases and plant parasitic ...
Liu Q, Johnson R, Adusei-Fosu K.
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Natural Product Communications, 2021 Huperzine A, isolated from Huperzia serrata, is a potent, specific, and reversible inhibitor of acetylcholinesterase with high efficiency and low toxicity.
Ngoc Chuong Nguyen +5 more
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Natural Chiral Scaffolds in Alzheimer's Disease: Therapeutic Potential, Mechanism, and Clinical Aspects. [PDF]
Biomed Res IntAlzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Singh A, Sahu SK, Sah AK.
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