Endophytic Fungal Community of Huperzia serrata: Diversity and Relevance to the Production of Huperzine A by the Plant Host [PDF]
Molecules, 2021 As the population ages globally, there seem to be more people with Alzheimer’s disease. Unfortunately, there is currently no specific treatment for the disease. At present, Huperzine A (HupA) is one of the best drugs used for the treatment of Alzheimer’s
Lingli Cui +8 more
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Comprehensive relative quantitative metabolomics analysis of lycopodium alkaloids in different tissues of Huperzia serrata [PDF]
Synthetic and Systems Biotechnology, 2018 Qian ceng Ta, the whole plant of Huperzia serrata, is an important landscape and medicinal herbs and contains abundant bioactive lycopodium alkaloids. Although the structures of more than 100 lycopodium alkaloids in Huperzia serrata have been isolated ...
Shiwen Wu, Zhen Fan, Youli Xiao
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Illumina-based analysis yields new insights into the diversity and composition of endophytic fungi in cultivated Huperzia serrata. [PDF]
PLoS ONE, 2020 Endophytic fungi play an important role in plant growth. The composition and structure of endophytes vary in different plant tissues, which are specific habitats for endophyte colonization.
Shipeng Fan +5 more
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Systematic Investigations of the Huperzine A—Producing Endophytic Fungi of Huperzia serrata in China and Fermentation Optimization Using OSMAC Strategy [PDF]
MoleculesHuperzine A (HupA) can alleviate Alzheimer’s disease due to its reversible inhibition of acetylcholinesterase (AChE). The chemical synthesis and plant extraction of HupA is plagued by route complexity and resource scarcity, respectively.
Wei Li +3 more
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The complete chloroplast genome of an Arctic lycophyte, Huperzia arctica (Tolm.) Sipliv. 1973 (Lycopodiaceae) [PDF]
Mitochondrial DNA. Part B. Resources, 2023 Huperzia arctica (Tolm.) Sipliv. 1973 is a lycophyte species belonging to the Lycopodiaceae family, which is widely distributed in the Arctic region of Svalbard, Norway.
Youngsim Hwang +3 more
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Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities [PDF]
Journal of Fungi, 2022 The secondary metabolites of Phaeosphaeria sp. LF5, an endophytic fungus with acetylcholinesterase (AChE) inhibitory activity isolated from Huperzia serrata, were investigated.
Yiwen Xiao +8 more
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Rhizospheric soil alter extracellular vesicles in the roots of Huperzia serrata and their carried miRNA [PDF]
Frontiers in GeneticsIntroductionAs a valuable traditional medicinal plant, it is unclear whether the roots of Huperzia serrata produce extracellular vesicles (EVs), or whether the addition of rhizospheric soil influences the characterization of EVs and the microRNAs (miRNAs)
Na Li +6 more
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Comparison of 454-ESTs from
BMC Plant Biology, 2010 Background Plants of the Huperziaceae family, which comprise the two genera Huperzia and Phlegmariurus, produce various types of lycopodium alkaloids that are used to treat a number of human ailments, such as contusions, swellings and strains.
Steinmetz André +7 more
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Evaluation of genetic diversity and structure of the endangered medicinal plant genus Huperzia (Lycopodiaceae) in China based on EST–SSR markers [PDF]
PhytoKeysHuperzia serrata is an endangered perennial medicinal lycophyte, primarily distributed across most regions of China, eastern and southern Asia, Oceania, and the Americas.
Muzi Li +12 more
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Selection of Reference Genes for Expression Analysis in Chinese Medicinal Herb Huperzia serrata [PDF]
Frontiers in Pharmacology, 2019 Huperzine A (HupA) is a powerful and selective inhibitor of acetylcholinesterase. It has attracted widespread attention endangering the ultimate plant sources of Lycopodiaceae family.
Mengquan Yang +8 more
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