Isolation and Characterization of Novel Huperzine-Producing Endophytic Fungi from Lycopodiaceae Species [PDF]
Journal of Fungi, 2023 Huperzine A (HupA) is an important drug for treating Alzheimer’s disease (AD) and is primarily extracted from the Huperzia serrata (Lycopodiaceae). Failures in the chemical synthesis of Hup and in vitro culture have put H. serrata in danger of extinction,
Thanh Thi Minh Le +4 more
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Functional Characterization and Mutagenesis Studies of a Microbial-like Diterpene Synthase from Huperzia serrata [PDF]
MoleculesOver the past decade, an increasing number of functional microbial-like terpene synthases (MTPSLs) have been reported in non-seed plants. However, whether the traditional Chinese medicinal plant H.
Ting He +5 more
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New PKS/NRPS Tenuazamines A–H from the Endophytic Fungus Alternaria alternata FL7 Isolated from Huperzia serrata [PDF]
Journal of FungiIn this paper, we present a novel class of hybrid polyketides, tenuazamines A–H (1–8), which exhibit a unique tautomeric equilibrium from Alternaria alternata FL7.
Hao Zhang +8 more
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Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrata [PDF]
Molecules, 2015 Two new tetranorlabdane diterpenoids, named botryosphaerins G (1) and H (2), were isolated from the solid fermentation products of Botryosphaeria sp. P483 along with seven known tetranorlabdane diterpenes (3–9).
Yan-Mei Chen +4 more
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Huperzia crassifolia (Lycopodiaceae), a new species from China based on morphological characters and molecular evidence [PDF]
PhytoKeysA new species of the firmoss from China, Huperzia crassifolia sp. nov., is described and illustrated based on morphological characters and molecular evidence. The new species resembles species associated with the H.
Zhi-You Guo +6 more
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Extended release huperzine for the treatment of idiopathic epilepsy in dogs – a Case Report [PDF]
Frontiers in Veterinary ScienceHuperzine is a naturally occurring alkaloid derived from the Chinese clubmoss Huperzia serrata. It is a potent acetylcholinesterase inhibitor, among other properties, and has demonstrated protection against induced seizures in a mouse model of Dravet’s ...
Kylie L. Grant, Sam N. Long
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A perspective on the mechanisms of herbal medicine for cognitive impairment [PDF]
Frontiers in NeurologyCognitive impairment (CI) represents a critical public health burden exacerbated by aging populations and inadequate therapeutic options. Conventional treatments usually target single molecules, which limits their effectiveness in addressing the complex ...
Si-yuan Zheng +2 more
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Co-cultivation Serratia marcescens with Trichoderma harzianum for improving production of Huperzine A [PDF]
Applied Microbiology and BiotechnologyPlant-derived (−)-Huperzine A (HupA), the bioactive enantiomer of the acetylcholinesterase inhibitor used for Alzheimer’s disease (AD) therapy, is limited by the scarcity of Huperzia serrata (HS), while chemically synthesized (+)-HupA is clinically ...
Han Wen-Xia +9 more
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Lecanicillium aphanocladii: a biocontrol agent against insect pests and phytopathogens. [PDF]
Pest Manag SciRecent research findings on the biocontrol potential of Lecanicillium aphanocladii fungus against insect‐pests and plant diseases were highlighted. This review indicates that several L. aphanocladii strains show great potential to be developed as multipurpose biocontrol agents active against several insect‐pests, plant diseases and plant parasitic ...
Liu Q, Johnson R, Adusei-Fosu K.
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Natural Chiral Scaffolds in Alzheimer's Disease: Therapeutic Potential, Mechanism, and Clinical Aspects. [PDF]
Biomed Res IntAlzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Singh A, Sahu SK, Sah AK.
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