Development of natural products as drugs acting on central nervous system
Memorias do Instituto Oswaldo Cruz, 1991 We have recenty studied several natural product constituents which have effects on the CNS. (1) Tetrahydropalmatine (THP) and its analogues were isolated from Corydalis ambigua and various species of Stephania.
Xing-Zu Zhu
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Huperzine A provides robust and sustained protection against induced seizures in Scn1a mutant mice
Frontiers in Pharmacology, 2016 De novo loss-of-function mutations in the voltage-gated sodium channel (VGSC) SCN1A (encoding Nav1.1) are the main cause of Dravet syndrome (DS), a catastrophic early-life encephalopathy associated with prolonged and recurrent early-life febrile seizures
Jennifer C. Wong +4 more
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Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats [PDF]
, 2014 Free radical induced neural damage is implicated in cerebral hypoperfusion disorders and antioxidants have protective effects. In the present study, we examined the effect of gallic acid (GA; 100 mg/kg, p.o. for 10 days) on cognitive deficit and cerebral
Farbood, Yaghoub. +4 more
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Bioactive Metabolites from Propolis Inhibit Superoxide Anion Radical, Acetylcholinesterase and Phosphodiesterase (PDE4) [PDF]
, 2013 Cycloartane-triterpenes (cycloartenol, 3α-cycloartenol-26-oic acid and 3β-cycloartenol-26-oic acid) together with α-amyrin acetate and flavonoids (pinostrobin, tectochrysin and chrysin) were isolated from Egyptian propolis for the first time.
Abd El-Hady, Faten K. +5 more
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Formulation of gliclazide using self-nano-emulsification technology [PDF]
, 2018 Self-nano-emulsifying drugs delivery systems present an effective drug delivery system for the formulation of a hydrophobic drug with poor water-solubility.
Abdel-Aziz, Farah +4 more
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Huperzine A: is it an effective disease-modifying drug for Alzheimer’s disease?
Frontiers in Aging Neuroscience, 2014 Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is no cure. Huperzine A (HupA) is a natural inhibitor of acetylcholinesterase (AChE) derived from the Chinese folk medicine Huperzia serrata (Qian Ceng Ta).
Zhong Ming eQian, Ya eKe
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Obtenção e caracterização de micropartículas de PHB/Qt/Cetoprofeno [PDF]
, 2010 TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.O objetivo do presente trabalho foi obter micropartículas compostas com um fármaco e controlar liberação do mesmo, otimizando a ...
Lins, Luanda Chaves Vieira
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1,3-Dicarbonyl compounds in stereoselective domino and multicomponent reactions
, 2010 International audienceModern organic synthesis focuses on the discovery and the development of stereoselective multiple bond-forming transformations allowing the creation of several covalent bonds in a single operation.
Bonne, Damien +3 more
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Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]
, 2017 Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
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Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome
Annals of Clinical and Translational Neurology, 2019 De novo loss‐of‐function mutations in SCN1A are the main cause of Dravet syndrome, a catastrophic encephalopathy characterized by recurrent early‐life febrile seizures, a number of other afebrile seizure types that are often refractory to treatment, and ...
Jennifer C. Wong +2 more
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