Results 81 to 90 of about 4,132 (213)

Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Ferroptosis, a controlled cell death, is driven by iron and characterized by reactive oxygen species and lipid peroxidation. The impact of lipid peroxides, GSH/GPX4, and iron metabolism–targeting small molecule inhibitors is discussed. Nucleic acids, proteins, and phytochemicals are implicated as inhibitors of ferroptosis.
Anwar Ali, Quratulain Babar, Ayesha Saeed, Domenico Sergi, Nenad Naumovski, Isam A. Mohamed Ahmed, Ghalia Shamlan, Halah Abdulrahman Hafiz, Muhammad Faisal Manzoor, Joanna Trafialek, Felix Kwashie Madilo   +10 more
wiley   +1 more source

Role of the Calcium Plateau in the Neuronal Injury and Behavioral Morbidities Following Organophosphate Intoxication [PDF]

, 2016
Organophosphate (OP) chemicals include nerve agents and pesticides, and there is a growing concern of OP based chemical attacks against civilians. Current antidotes are essential in limiting immediate mortality associated with OP exposure.
Battaglia F.P., Campbell S., Dingeman A., Filbert M., Karki P., Konradsen F., Moorcraft P., Than K., Yamashita M.   +8 more
core   +2 more sources

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

Drug-Phospholipid Complex-loaded Matrix Film Formulation for the Enhanced Transdermal Delivery of Quercetin [PDF]

, 2018
A novel quercetin-phospholipid-complex(QPLC)-loaded matrix film for improved transdermal delivery of quercetin was developed. The QPLC formulation, prepared using a solvent-evaporation method, was optimized using a central-composite design. The optimized
Anand, Sridhar, Dave, Vivek S., Patil, Arun T., Telange, Darshan R., Umekar, Milind J., Wavare, Kuldeep D.   +5 more
core   +1 more source

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain [PDF]

, 2011
Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated
Anderson eWinkler, David eGlahn, David eGlahn, Elliott eHong, Henry eHolcomb, Jack eKent, Jason eStein, Joanne eCurran, John eBlangero, Melany eCarless, MP eJohnson, Paul eThompson, Peter eKochunov, Peter eKochunov, Peter eKochunov, Rene eOlvera, Shelley eCole, Tom eNichols, Valeria eKochunov   +18 more
core   +4 more sources

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology [PDF]

, 2017
The British Association for Psychopharmacology coordinated a meeting of experts to review and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs. As before, levels of evidence were rated using accepted standards which were
Burns, A, Holmes, C, Jones, M, Jones, R, Livingston, G, McKeith, I, Mittler, P, O'Brien, JT, Passmore, P, Ritchie, C, Robinson, L, Sampson, EL, Taylor, J-P, Thomas, A   +13 more
core   +2 more sources

Chronic Intermittent Hypoxia‐Induced Neural Injury: Pathophysiology, Neurodegenerative Implications, and Therapeutic Insights

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
Given the established association between obstructive sleep apnea‐hypopnea syndrome (OSAHS) and neurodegenerative pathogenesis, this review systematically investigates the mechanisms by which chronic intermittent hypoxia (CIH) contributes to OSAHS‐related neural injury.
Nan‐Nan Jia, Meng‐Fan Yao, Chun‐Xue Zhu, Mei‐Juan He, Hai‐Feng Zhu, Zun‐Yu Chen, Han‐Peng Huang, Chen Qiao   +7 more
wiley   +1 more source

Recent Advances in Sustainable Total Synthesis and Chiral Pool Strategies with Emphasis on (−)‐Sclareol in Natural Products Synthesis

European Journal of Organic Chemistry, Volume 28, Issue 8, February 24, 2025.
There are continuous efforts to improve total syntheses of natural products, particularly their sustainability, such as developing effective chiral pool approaches relying on a wide spectrum of natural chirons, including (−)‐sclareol as one of the most useful natural chirons.
Ayyoub Selka, Abdelnasser Abidli, Lucie Schiavo, Loïc Jeanmart, Gilles Hanquet, William D. Lubell   +5 more
wiley   +1 more source

Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]

, 2016
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar, Dave, Vivek S., Fegade, Harshal, Patin, Arun T., Pethe, Anil M., Telange, Darshan R.   +5 more
core   +2 more sources