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Renal abscesses and endogenous endophthalmitis due to hypermucoviscous hypervirulent Klebsiella pneumoniae (HVKP)

IDCases, 2021
We describe a diabetic patient with left eye endogenous endophthalmitis due to hypervirulent hypermucoviscous Klebsiella pneumoniae (HKVP) originating from right renal abscesses. A rare source of HVKP causing endogenous endophthalmitis. Despite treatment with intravenous ceftazidime and pars plana vitrectomy, the patient required evisceration of the ...
Fadi Fouad Hassanin, Dareen Khawjah
exaly   +4 more sources

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Itaconate inhibits SYK through alkylation and suppresses inflammation against hvKP induced intestinal dysbiosis

Cellular and Molecular Life Sciences, 2023
Hypervirulent Klebsiella pneumoniae (hvKP) is a highly lethal opportunistic pathogen that elicits more severe inflammatory responses compared to classical Klebsiella pneumoniae (cKP). In this study, we investigated the interaction between hvKP infection and the anti-inflammatory immune response gene 1 (IRG1)-itaconate axis. Firstly, we demonstrated the
Yangguang Li, Peizhao Liu, Xiuwen Wu
exaly   +3 more sources

Lowering mortality risk in CR-HvKP infection in intestinal immunohistological and microbiota restoration

Pharmacological Research
Gut damage during carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-HvKP) infection is associated with a death risk. Understanding the mechanisms by which CR-HvKP causes intestinal damage and gut microbiota alteration, and the impact on immunity, is crucial for developing therapeutic strategies.
Hongyuhang Ni, Sheng Chen
exaly   +5 more sources

Rapid Detection to Differentiate Hypervirulent Klebsiella pneumoniae (hvKp) From Classical K. pneumoniae by Identifying peg-344 With Loop-Mediated Isothermal Amplication (LAMP) [PDF]

Frontiers in Microbiology, 2020
To establish a rapid molecular diagnostics of hvKp using the peg-344 loop-mediated isothermal amplification technique (LAMP).In all, 28 K. pneumoniae strains isolated from the blood of patients were used for the peg-344 LAMP. K. pneumoniae NTUH-K2044 and K. pneumoniae ATCC700603 were used as positive control and negative control, respectively.
Wen-Jian Liao
exaly   +4 more sources

Genotypic characterization of hypervirulent Klebsiella pneumoniae (hvKp) in a tertiary care Indian hospital

International Microbiology
Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen and causes endophthalmitis, liver abscess, osteomyelitis, meningitis, and necrotizing soft tissue infections in both immunodeficient and healthy people. The acquisition of the antibiotic resistance genes of hvKp has become an emerging concern throughout the globe. In this study, a total
Rajashree Panigrahy, Rajesh Kumar Sahoo, Birasen Behera   +2 more
exaly   +3 more sources

Capture of mobile genetic elements following intercellular conjugation promotes the production of ST11-KL64 CR-hvKP

Microbiology Spectrum
ABSTRACT Sequence type (ST)11 carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) can cause life-threatening infections and is therefore of global concern. Despite its importance, the evolutionary history and mechanism for the emergence of ST11 CR-hvKP are ...
Shanshan Huang, Dan Dan Wei, Hanxu Hong, Si Chen, Lin-Ping Fan, Qi-Sen Huang, Fang-Ling Du, Tian-Xin Xiang, Ping Li, Wei Zhang, La-Gen Wan, Yang Liu   +11 more
exaly   +4 more sources

A novel and rapid fluorescent PfAgo detection system for hypervirulent Klebsiella pneumoniae (hvKP)

Microchemical Journal
Tiandan Yang, Zhihong Zhu, Yanbei Chen, Jie Lin, Yongmei Zeng, Jiayu Liao, Liying Chen, Jinlian Fang, Yuzhong Zheng, Liyun Lin, Qiulan Luo, Guangyu Sun, Weizhong Chen, Xianyao Wang, Jie Su, Liejun Li, Min Lin, Chuangxing Lin   +17 more
exaly   +2 more sources

Hypervirulent klebseilla pneumoniae (hvKp) is a new threat

Sohag Medical Journal, 2023
dina mohamed, Mona Mohamed, Nessma hassan, Ashgan Badawy   +3 more
openaire   +1 more source

Protocatechuic acid induces endogenous oxidative stress in CR-hvKP by regulating the EMP-PPP pathway

ABSTRACTBackgroundKlebsiella pneumoniae is an important opportunistic pathogen and zoonotic pathogen. The widespread use of antibiotics has led to the emergence of a large number of multidrug-resistant Klebsiella pneumoniae in clinical animal husbandry, posing a serious threat to global health security.
Yesheng Zhong, Yumeng Cheng, Shuai Xing, Xiaoxiao Zhang, Shiqi Luo, Xinru Shi, Yang He, Huixin Liu, Meng Yang, Hongbin Si   +9 more
openaire   +1 more source

Clinical and Molecular Characterisation of Multi Drug Resistant Hypervirulent Klebsiella pneumoniae (MDR-HvKp) Isolated from Patient Attending ATBU Teaching Hospital Bauchi

European Journal of Microbiology and Infectious Diseases
Background and Aim: K. pneumoniae exhibits increasing multidrug resistance and a global rise in hypervirulent strains, particularly prevalent in various African countries, posing significant challenges in managing infections ranging from pneumonia to neonatal septicemia and urinary tract infections.
Nazeef Usman, Ahmed Umar, Mahmud Iliyasu
openaire   +1 more source