Results 41 to 50 of about 2,309,824 (325)

Chain Gangs: New Aspects of Hyaluronan Metabolism

Biochemistry Research International, 2012
Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
doaj   +1 more source

The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins

Frontiers in Cell and Developmental Biology, 2022
Oligodendrocytes are myelin-forming cells in the central nervous system (CNS). The development of oligodendrocytes is regulated by a large number of molecules, including extracellular matrix (ECM) proteins that are relatively less characterized. Here, we
Momona Yamada, Miho Iwase, Binri Sasaki, Nobuharu Suzuki   +3 more
doaj   +1 more source

Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. [PDF]

, 2013
Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost ...
Carmichael, S Thomas, Moshayedi, Pouria
core   +1 more source

Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization [PDF]

Journal of Biological Chemistry, 2016
The lymphatic endothelial receptor LYVE-1 has been implicated in both uptake of hyaluronan (HA) from tissue matrix and in facilitating transit of leukocytes and tumor cells through lymphatic vessels based largely onin vitrostudies with recombinant receptor in transfected fibroblasts.
Lawrance, William, Banerji, Suneale, Day, Tony, Bhattacharjee, Shaumick, Jackson, David   +4 more
openaire   +4 more sources

Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation

Cell Death Discovery, 2021
The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with cell membrane receptors as CD44
Matías Arturo Pibuel, Daniela Poodts, Mariángeles Díaz, Yamila Azul Molinari, Paula Gabriela Franco, Silvia Elvira Hajos, Silvina Laura Lompardía   +6 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Drug conjugation to hyaluronan widens therapeutic indications for ovarian cancer [PDF]

, 2015
Management of ovarian cancer still requires improvements in therapeutic options. A drug delivery strategy was tested that allows specific targeting of tumor cells in combination with a controlled release of a cytotoxic molecule. To this aim, the efficacy
Campisi, Monica, Carpanese, Debora, Merlo, Anna, Montagner, Isabella Monia, Pasut, Gianfranco, Renier, Davide, Rosato, Antonio, Zanovello, Paola, Zuccolotto, Gaia   +8 more
core   +2 more sources

SPERM SELECTION WITH HYALURONAN AND BLASTOCYST DEVELOPMENT AFTER ICSI

Zdravniški Vestnik, 2018
Background. Selection of mature sperm for intracytoplasmic sperm injection (ICSI) has recently been made possible by hyaluronan, a naturally occurring substance found in the cumulus cells.
Lili Bačer Kermavner, Irma Virant Klun, Eda Vrtačnik Bokal, Tomaž Tomaževič, Helena Meden Vrtovec   +4 more
doaj   +1 more source

Hyaluronan goes to great length

Cell Stress, 2020
Hyaluronan is a major non-protein component of extracellular matrix that affects biomechanical properties of tissues and interacts with cell receptors.
Vera Gorbunova, Masaki Takasugi, Andrei Seluanov   +2 more
doaj   +1 more source

GBS hyaluronidase mediates immune suppression in a TLR2/4- and IL-10-dependent manner during pregnancy-associated infection

mBio, 2023
Bacterial infections remain a significant cause of adverse pregnancy outcomes. Ascending infection of group B streptococcus (GBS) or Streptococcus agalactiae from the lower genital tract to the amniotic cavity leads to fetal injury, preterm births, or ...
Michelle Coleman, Austyn Orvis, Alyssa Brokaw, Anna Furuta, Kavita Sharma, Phoenicia Quach, Avneet Bhullar, Rhea Sanghavi, Shayla Nguyen, Erin Sweeney, Ravin Seepersaud, Blair Armistead, Kristina M. Adams Waldorf, Lakshmi Rajagopal   +13 more
doaj   +1 more source