Results 71 to 80 of about 27,059 (274)

Nanozyme‐Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy

Advanced Science, EarlyView.
A nanozyme–integrated hydrogel (PTC‐MP) exhibiting with mild photothermal effects is constructed, and a “3R” (restrain‐restore‐reinforce) strategy is proposed for diabetic osteoarthritis (DOA) treatment based on advanced glycation end products (AGEs) targeting.
Rui Chen, Yanguo Su, Guiyuan Zhao, Jiaojiao Tao, Qijie Diao, Guangli Xiang, Tianze Jiang, Lu Han, Xia Zhao   +8 more
wiley   +1 more source

Supplementary Figure 6 from TGFβ and Hippo Pathways Cooperate to Enhance Sarcomagenesis and Metastasis through the Hyaluronan-Mediated Motility Receptor (HMMR)

, 2023
Shuai Ye, Ying Liu, Ashley M. Fuller, Rohan Katti, Gabrielle E. Ciotti, Susan Chor, Md. Zahidul Alam, Samir Devalaraja, Kristin Lorent, Kristy Weber, Malay Haldar, Michael Pack, T.S. Karin Eisinger‐Mathason   +12 more
openalex   +2 more sources

Fluid bolus increases plasma hyaluronan concentration compared to follow-up strategy without a bolus in oliguric intensive care unit patients

Scientific Reports
Fluid therapy is a fundamental part of supportive therapy in critical care. However, it is also a suspected risk for endothelial glycocalyx degradation which is associated with poor clinical outcomes.
Maija Serlo, Nina Inkinen, Päivi Lakkisto, Miia Valkonen, Anni Pulkkinen, Tuomas Selander, Ville Pettilä, Suvi T. Vaara   +7 more
doaj   +1 more source

Hyaluronan Receptors on Liver Endothelial Cells.

Trends in Glycoscience and Glycotechnology, 1996
結合組織の多糖類であるヒアルロナン (ヒアルロン酸、HA)は、肝臓の内皮細胞 (LEC) が受容体を介したエンドサイトーシスを行うことにより、循環系から極めて効果的に除かれる。肝硬変のような肝疾患が起こると、LECによるHAの取り込みが減少してHAの血清濃度が増加する。少なくとも2種の異なる受容体活性がLEC表層には存在する。そのひとつはカルシウム依存性で直接にはエンドサイトーシスには関与していないようである。もう一つはカルシウム非依存性でエンドサイトーシスを仲介する。受容体はコンドロイチン硫酸やデキストラン硫酸のようなHA以外のリガンドも認識するので、その点でスキャベンジャー受容体に似ている。高分子量HAは低分子量HAより受容体に対して高い親和性を持ち、受容体が認識する最小のオリゴ糖は6糖である ...
openaire   +2 more sources

Photothermal Transport for Guiding Nanoparticles Through the Vitreous Humor

Advanced Science, EarlyView.
Nanosecond laser irradiation of the clinically approved dye indocyanine green (ICG) enables light‐guided nanoparticle transport within the vitreous humor. The combined use of ICG and pulsed laser illumination induces localized convection and thermophoresis, directing particles toward illuminated regions.
Léa Guerassimoff, Yera Ussembayev, Louise De Clerck, Deep Punj, Martijn van den Broek, Filip Beunis, Katrien Remaut, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage   +9 more
wiley   +1 more source

Receptor for Hyaluronan Mediated Motility (RHAMM)/Hyaluronan Axis in Breast Cancer Chemoresistance

Cancers
Background/Objectives: Receptor for hyaluronan-mediated motility (RHAMM) is a hyaluronan (HA) receptor, which exerts diverse biological functions in not only physiological but also pathological conditions in human malignancies, including breast cancer.
Shiori Fujisawa, Kiyoshi Takagi, Mio Yamaguchi-Tanaka, Ai Sato, Yasuhiro Miki, Minoru Miyashita, Hiroshi Tada, Takanori Ishida, Takashi Suzuki   +8 more
openaire   +2 more sources

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Hyaluronan–cisplatin conjugate nanoparticles embedded in Eudragit S100-coated pectin/alginate microbeads for colon drug delivery

International Journal of Nanomedicine, 2013
Shiao-Wen Tsai,1 Ding-Syuan Yu,2 Shu-Wei Tsao,1 Fu-Yin Hsu2,3 1Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan; 2Department of Life Science, 3Institute of Bioscience and Biotechnology, National Taiwan ...
Tsai SW, Yu DS, Tsao SW, Hsu FY
doaj  

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source