Results 81 to 90 of about 2,309,824 (325)
The Role of Hyaluronan Treatment in Intestinal Innate Host Defense
Frontiers in Immunology, 2020 Hyaluronan (HA) is best known as an abundantly present extracellular matrix component found throughout the body of all vertebrates, including humans.
Yeojung Kim, Carol A. de la Motte
doaj +1 more source
Hyaluronan Receptors on Liver Endothelial Cells
, 1996 結合組織の多糖類であるヒアルロナン (ヒアルロン酸、HA)は、肝臓の内皮細胞 (LEC) が受容体を介したエンドサイトーシスを行うことにより、循環系から極めて効果的に除かれる。肝硬変のような肝疾患が起こると、LECによるHAの取り込みが減少してHAの血清濃度が増加する。少なくとも2種の異なる受容体活性がLEC表層には存在する。そのひとつはカルシウム依存性で直接にはエンドサイトーシスには関与していないようである。もう一つはカルシウム非依存性でエンドサイトーシスを仲介する ...
S. Gustafson, 貞子 山形
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho +7 more
wiley +1 more source
TGF-beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan. [PDF]
The Journal of cell biology, 1993 TGF-beta is a potent stimulator of motility in a variety of cell types. It has recently been shown that hyaluronan (HA) can directly promote locomotion of cells through interaction with the HA receptor RHAMM. We have investigated the role of RHAMM and HA in TGF-beta-stimulated locomotion and show that TGF-beta triggers the transcription, synthesis and ...
Arnold H. Greenberg +5 more
openaire +3 more sources
Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro
Advanced Healthcare Materials, EarlyView.A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski +3 more
wiley +1 more source
The role of hyaluronan in renal cell carcinoma
Frontiers in Immunology, 2023 Renal cell carcinoma (RCC) is associated with high mortality rates worldwide and survival among RCC patients has not improved significantly in the past few years.
Chenchen Jin, Yunfeng Zong
doaj +1 more source
International Journal of Molecular Sciences, 2020 The demonstrated expression of endocannabinoid receptors in myofascial tissue suggested the role of fascia as a source and modulator of pain. Fibroblasts can modulate the production of the various components of the extracellular matrix, according to type
C. Fede +6 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra +7 more
wiley +1 more source
Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
Biomolecules, 2021 Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer.
Cornelia Tolg +4 more
doaj +1 more source
Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases
Advanced Materials, EarlyView.This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu +16 more
wiley +1 more source