Results 101 to 110 of about 19,597 (211)

An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli.

The Journal of biological chemistry, 2004
The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic domain that elongates two different monosaccharides. As for the synthetic mechanism, there are two alternative manners for the sugar elongation process.
Hiroko, Hoshi, Hiroaki, Nakagawa, Susumu, Nishiguchi, Kazumichi, Iwata, Kenichi, Niikura, Kenji, Monde, Shin-Ichiro, Nishimura   +6 more
openaire   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells [PDF]

, 2013
Thickening of the vessel in response to high low density lipoprotein(s) (LDL) levels is a hallmark of atherosclerosis, characterized by increased hyaluronan (HA) deposition in the neointima.
Bartolini, B., De Luca, G., Deleonibus, S., Hascall, V.C., Karousou, E., Moretto, P., Passi, A., Sawamura, T., Vigetti, D., Viola, M., Wight, T.N.   +10 more
core   +1 more source

The complex TIE between macrophages and angiogenesis [PDF]

, 2020
Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration.
Anghelina M., Avraham‐Davidi I., Baer C., Bailey A. S., Barnett F. H., Bonnardel J., Chakarov S., Chen L., Coffelt S. B., Corliss B. A., Cursiefen C., Daly C., Davies L. C., Davies L. C., De Palma M., De Palma M., De Palma M., De Palma M., De Palma M., De Spiegelaere W., DeFalco T., Deshmane S. L., Detry B., Dimova I., Dimova I., Eklund L., Elamaa H., Eubank T. D., Fantin A., Ferrari G., Fukuhara S., Ganta V. C., Ganta V. C., García S., Gerri C., Grunewald M., Guo L., Gurevich D. B., Hamm A., Hazan A. D., He H., Hoeffel G., Itoh M., Jetten N., Kim M., Kochhan E., Korhonen E. A., Korpelainen E. I., Krishnasamy K., Kumar A. H., Leibovich S. J., Lim H. Y., Liu C., Lucas T., Master Z., Metharom P., Michaeli S., Moldovan N. I., Moore E. M., Mueller S. B., Murdoch C., Murray P. J., Patel A. S., Polverini P. J., Potente M., Pucci F., Saharinen P., Saharinen P., Schif‐Zuck S., Schmeisser A., Seaman S. A., Seok S. H., Spiller K. L., Venneri M. A., Vestweber D., Webster N. L., West M. E. D., Willenborg S., Yamamoto S., Zajac E., Zenker D., Zhang W.   +81 more
core   +2 more sources

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

MedComm, Volume 7, Issue 2, February 2026.
Increased miR‐3163 targets NUDT21, reducing CPSF5 levels and driving APA dysregulation. This results in 3′UTR shortening of CBFB, which stabilizes RUNX1 and promotes smooth muscle proliferation. PTGER3, is also shortened amplifying hypoxia‐induced RVSP. Together, these pathways contribute to vascular remodeling in PH. Image Created in https://BioRender.
Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty‐Quintana   +17 more
wiley   +1 more source

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep [PDF]

, 2017
An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising.
Fouladi-Nashta, A A, Ghafari, F, Marei, W F A, Mohey-Elsaeed, O, Raheem, K A, Wathes, D C   +5 more
core   +3 more sources

The Role of the Gut Microbiome in the Complex Network of Frailty Syndrome and Associated Comorbidities in Aging

Aging Cell, Volume 25, Issue 2, February 2026.
This study analyzed gut microbiota in older adults with and without Frailty Syndrome by 16S rRNA gene sequencing and metagenomics. Frailty was associated with altered microbial composition, metabolic functions, and increased antimicrobial resistance, whereas non‐frail individuals showed healthier profiles.
Ana Barberá, Rosario Ortolá, Mercedes Sotos‐Prieto, Fernando Rodríguez‐Artalejo, Andrés Moya, Susana Ruiz‐Ruiz   +5 more
wiley   +1 more source

Clinical significance of hyaluronan levels and its pro-osteogenic effect on mesenchymal stromal cells in myelodysplastic syndromes

Journal of Translational Medicine, 2018
Background Hyaluronan (HA), a major component of the extracellular matrix, has been proven to play a crucial role in tumor progression. However, it remains unknown whether HA exerts any effects in myelodysplastic syndromes (MDS).
Cheng-Ming Fei, Juan Guo, You-Shan Zhao, Si-Da Zhao, Qing-Qing Zhen, Lei Shi, Xiao Li, Chun-Kang Chang   +7 more
doaj   +1 more source

Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells [PDF]

, 2015
Protein O-glycosylation has key roles in many biological processes, but the repertoire of O-glycans synthesized by cells is difficult to determine. Here we describe an approach termed Cellular O-Glycome Reporter/Amplification (CORA), a sensitive method ...
Antonopoulos, A, Cummings, RD, Dell, A, Duong, DM, Haslam, SM, Ju, T, Kudelka, MR, Seyfried, NT, Song, X, Wang, Y   +9 more
core   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source