Results 111 to 120 of about 19,597 (211)

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc [PDF]

, 2014
Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space.
Hanson, R.W., Hart, G.W., Hascall, V.C., Oikari, S., Passi, A., Tammi, M., Tammi, R., Vigetti, D., Wang, A.   +8 more
core   +1 more source

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication [PDF]

, 2017
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Arranz, Baig, Banerjee, Baranova, Barritt, Beebe, Beurdeley, Blosa, Bradbury, Brakebusch, Brückner, Brückner, Bukalo, Bukalo, Cabungcal, Caillard, Carstens, Carulli, Carulli, Carulli, Chang, Cheah, Corvetti, Coulson-Thomas, Dauth, Day, de Winter, Deepa, Deepa, Dick, Dityatev, Donato, Favuzzi, Foscarin, Frischknecht, Galtrey, Galtrey, Geissler, Giamanco, Gogolla, Grøndahl, Gu, Gurevicius, Happel, Heleen M. van 't Spijker, Hensch, Hisaoka, Hylin, Härtig, Härtig, Jansen, Jessica C. F. Kwok, Kochlamazashvili, Kwok, Kwok, Lafarga, Lander, Lee, Lensjø, Lensjø, Mabuchi, Matthews, McRae, Miyata, Miyata, Miyata, Morawski, Morawski, Morawski, Morikawa, Orlando, Pantazopoulos, Pelkey, Pizzorusso, Pizzorusso, Romberg, Rossier, Shinozaki, Smith, Spatazza, Spreafico, Steullet, Sugiyama, Suttkus, Suzuki, Vo, Wang, Yamada, Ye   +88 more
core   +2 more sources

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes [PDF]

, 2013
INTRODUCTION: Hypoxia is considered to be a positive influence on the healthy chondrocyte phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have been implicated in the pathogenesis of osteoarthritis (OA).
Brandon D Markway, Brian Johnstone, Holly Cho   +2 more
core   +1 more source

The Role of Anethole in Reproductive Physiology and In Vitro Biotechnologies—A Review

Reproduction in Domestic Animals, Volume 61, Issue 1, January 2026.
ABSTRACT In vitro reproductive biotechnologies show promise for fertility preservation but still face challenges, including oxidative stress from high oxygen tension, which impairs cell viability and development. Antioxidants have been widely explored to attenuate oxidative stress during culture.
André Luiz da Conceição‐Santos, José Ricardo de Figueiredo   +1 more
wiley   +1 more source

Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Molecular Medicine
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao, Weiqing Wu, Jiyun Lin, Yuankai Yang, Sheng Lin, Jindi Su, Yueyuan Qin, Baojiang Wang, Shan Duan   +8 more
doaj   +1 more source

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]

, 2015
Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi, Christiansen, Blaine, Emami, Shahin, Goudarzi, Ramin   +3 more
core   +1 more source

Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells

Matrix Biology Plus, 2019
High levels of hyaluronan (ΗΑ), a major extracellular matrix (ECM) glycosaminoglycan, have been correlated with poor clinical outcome in several malignancies, including breast cancer.
Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos   +9 more
doaj   +1 more source